408492-27-3 - Names and Identifiers
Name | 2,6-Dichloropyridine-4-boronic acid, pinacol ester
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Synonyms | 2,6-Dichloropyridine-4-boronicacidpinacolester 2,6-Dichloropyridine-4-boronic acid,pinacol ester 2,6-Dichloropyridine-4-boronic acid, pinacol ester 2,6-Dichloropyridinyl-4-boronic acid pinacol ester (2,6-DICHLOROPYRIDIN-4-YL)BORONIC ACID PINACOL ESTER 2,6-Dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) 2,6-DICHLORO-4-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-(2,6-Dichloro-4-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 2,6-DICHLORO-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Pyridine, 2,6-dichloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
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CAS | 408492-27-3
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InChIKey | PEFDHAOFDBNZEQ-UHFFFAOYSA-N |
408492-27-3 - Physico-chemical Properties
Molecular Formula | C11H14BCl2NO2
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Molar Mass | 273.95 |
Density | 1.24±0.1 g/cm3(Predicted) |
Melting Point | 117-119°C |
Boling Point | 373.2±42.0 °C(Predicted) |
pKa | -3.74±0.10(Predicted) |
Storage Condition | 2-8°C |
408492-27-3 - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
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WGK Germany | 3 |
408492-27-3 - Introduction
2. Acid, pinacol ester is an organic compound with a chemical formula of C10H12BCl2NO2 and a molecular weight of 246.92g/mol. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: Colorless or light yellow solid
-Melting point: about 60-62 ℃
-Solubility: Soluble in common organic solvents such as chloroform, ether and methanol, insoluble in water
-Stability: stable at room temperature, but avoid prolonged exposure to strong light and high temperature environment
Use:
- 2, acid, pinacol ester is an important organic synthesis intermediate, which can be used to synthesize various boron-containing organic compounds. It is often used as one of the substrates for Suzuki coupling reactions and can react with aromatic or hydrogenated pyridinium halides to generate the corresponding pyridine-4-boronic acid ester compounds.
Preparation Method:
- 2, acid, pinacol ester can be synthesized through the following steps:
1. In the presence of sulfuric acid or concentrated hydrochloric acid, 2,6-dichloropyridine reacts with boronic acid pinacol to generate 2,6-dichloropyridine -4-borate.
2.6-dichloropyridine -4-borate reacts with tetramine (pinacol) alcohol to generate 2, acid, pinacol ester.
Safety Information:
- 2, acid, pinacol ester is irritating and may cause damage to the eyes, skin and respiratory tract. Wear appropriate personal protective equipment when using, and try to avoid direct contact. During operation, care should be taken to avoid inhalation of gas, steam, mist, dust and smoke. At the same time, it should also be stored in a dry, well-ventilated place, away from heat and fire sources. When handling this compound, safe operating procedures should be followed and relevant safety guidelines and regulations should be strictly followed.
Last Update:2024-04-10 22:29:15