Name | 2-benzoyl-5-methoxy-1-phenol-4-sulfonic acid |
Synonyms | BP-4 UV-284 Uvistat 1121 Sulisobenzone UV ABSORBER HMBS TIMTEC-BB SBB002961 spectra-sorb uv 284 Uv absorber BP-4(UV-284) 2-Hydroxy-4-Methoxybenzophenone-5-Sulfonic Acid 2-HYDROXY-4-METHOXYBENZOPHENONE-5-SULPHONIC ACID 2-Hydroxy-4-Methoxy Benzophenone-5-Sulfonic acid 5-BENZOYL-4-HYDROXY-2-METHOXYBENZENESULFONIC ACID 2-Hydroxy-4-methoxybenzophenone-5-sulfonic Acid Hydrate UV Absorber D-49 |
CAS | 4065-45-6 |
EINECS | 223-772-2 |
InChI | InChI=1/C14H12O6S/c1-20-12-8-11(15)10(7-13(12)21(17,18)19)14(16)9-5-3-2-4-6-9/h2-8,15H,1H3,(H,17,18,19)/p-1 |
InChIKey | CXVGEDCSTKKODG-UHFFFAOYSA-N |
Molecular Formula | C14H12O6S |
Molar Mass | 308.31 |
Density | 1.4574 (rough estimate) |
Melting Point | 170 °C |
Boling Point | 0°C |
Flash Point | 0°C |
Water Solubility | 300.92g/L at 25℃ |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 0Pa at 25℃ |
Appearance | White to Yellowish Powder |
Color | White to Off-White |
Merck | 14,8983 |
BRN | 2889165 |
pKa | -0.70±0.50(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.5300 (estimate) |
MDL | MFCD00024962 |
Physical and Chemical Properties | This product is light yellow crystal. |
Use | Is a broad-spectrum UV absorber, with high absorption efficiency, non-toxic, no teratogenic side effects, good light, thermal stability and other advantages, it can absorb UV-A and UV-B, it is a Class I sunscreen approved by FDA in the United States and Europe. It is widely used in sunscreen creams, creams, honey, lotions, oils and other sunscreen cosmetics |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. |
WGK Germany | 1 |
RTECS | DB5044300 |
TSCA | Yes |
HS Code | 29147000 |
1. Synthesis of Benzene Dimethyl Ether
Add 350kg of water to the reaction kettle and add 150kg of NaOH under stirring. After dissolution, cool to 10 ℃, add 110kg of resorcinol, and stir to dissolve. Then slowly add 126kq dimethyl sulfate and react for 2 hours at 26-30 ℃. Dilute with water, separate the oil layer, and wash the oil layer with water to neutral. Remove the low boiling point substance and distill and collect the fraction at 215~220 ℃, which is m-phenyldimethyl ether.
2. Synthesis of 2-hydroxy-4-methoxy benzophenone
Firstly, 300kg of chlorobenzene was added to the condensation kettle, and catalyst AlCl3350kg and 120kg of m-phenylene ether were added under stirring. Heat to around 80 ℃ and slowly add 320kg of benzoyl chloride. Reflux for 4-6 hours, cool, hydrolyze, evaporate solvent, cool, crystallize, and dry to obtain 2-hydroxy-4-methoxy benzophenone.
3. Synthesis of 2-hydroxy-4-methoxy-5-sulfonic acid diphenylacetone
Firstly, add 93% sulfuric acid to the sulfonation kettle, and slowly add 2-hydroxy-4-methoxy benzophenone with stirring. React at around 110 ℃ for 4-6 hours, cool, crystallize, shake dry, and recrystallize to obtain the finished product.
It is irritating and should not come into direct contact with the skin. Place in a cool and ventilated warehouse, do not store with flammable materials, and keep away from ignition sources.