Name | 4-Chloro-3-nitropyridine |
Synonyms | 4-Chlor-3-nitro-pyridin 4-Chlor-3-nitropyridine 4-Chloro-3-nitropyridine 4-CHLORO-3-NITROPYRIDINE 4-chloro-3-nitro-pyridine Pyridine, 4-chloro-3-nitro- 4-Chloro-3-nitropyridine, tech. 4-CHLORO-3-NITROPYRIDINE 4-CHLORO-3-NITROPYRIDINE 4-Chloro-3-Nitropyridine, May Cont. Variable Amounts of Oligomers |
CAS | 13091-23-1 |
EINECS | 603-447-5 |
InChI | InChI=1/C5H3ClN2O2/c6-4-1-2-7-3-5(4)8(9)10/h1-3H |
InChIKey | JOTRPRKONYTVBV-UHFFFAOYSA-N |
Molecular Formula | C5H3ClN2O2 |
Molar Mass | 158.54 |
Density | 1.489±0.06 g/cm3(Predicted) |
Melting Point | 35-50 °C |
Boling Point | 95 °C(Press: 5 Torr) |
Flash Point | 102.9°C |
Water Solubility | Insoluble in water. |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Vapor Presure | 0.0426mmHg at 25°C |
Appearance | Brown powder |
Color | Pale yellow |
pKa | 0.56±0.10(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.587 |
MDL | MFCD02683025 |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36/39 - S37/38 - S36 - Wear suitable protective clothing. |
UN IDs | UN 2811 |
WGK Germany | 3 |
HS Code | 29333990 |
Hazard Note | Irritant |
Hazard Class | IRRITANT, KEEP COLD |
Packing Group | III |
Application | 4-chloro-3-nitropyridine is a heterocyclic organic compound and can be used as a pharmaceutical intermediate. |
Uses | 4-chloro-3-nitropyridine is a very important class of pyridine derivatives, which can be used as a viscosity regulator to synthesize anti-peptic ulcer drugs Pirenzepine, diazepine anti-AIDS drugs, leukotriene biosynthesis inhibitors, and can be used as drug intermediates for pesticides. Therefore, it is of great significance to study the synthesis of 4-chloro -3-nitropyridine. |
preparation | (1) mix and stir 5mol of 4-hydroxypyridine and ionic liquid evenly, add concentrated nitric acid while stirring, continue stirring for 10min, add 1mol of mesoporous silica, raise the temperature to 95 ℃, stir for 2 hours, cool to room temperature, add concentrated ammonia water while stirring in an ice salt bath, adjust the pH to 5-7, add deionized water, stir until the precipitation is complete, filter, wash the precipitation with deionized water for 2-5 times, and dry to obtain 4-hydroxy-3-nitropyridine, add deionized water, use dichloromethane for extraction, and then remove dichloromethane under negative pressure to obtain 4-chloro-3-nitropyridine. |