4-bromo-6-(trifluoromethyl)pyrimidine is an organic compound with the chemical formula C5H2BrF3N2. It is a colorless crystalline solid, stable at room temperature.
The main use of this compound is as a starting material or intermediate in organic synthesis. It can be used in the manufacture of pesticides, pharmaceuticals and other organic compounds. For example, it can be used in the synthesis of pyrimidine anticancer drugs.
The preparation method thereof can be achieved by reacting 4-bromo-6-nitropyrimidine with trifluoromethyllithium. First, 4-bromo-6-nitropyrimidine was dissolved in sodium carbonate solution, then trifluoromethyllithium was added for reaction, and finally the target product was obtained by acidification treatment.
When using and handling this compound, you need to pay attention to the following safety information. 4-bromo-6-(trifluoromethyl)pyrimidine is irritating to the skin and eyes, so wear protective gloves and goggles when handling. Avoid inhalation and ingestion and ensure use in a well-ventilated area. In the case of accidental contact or ingestion, seek medical advice immediately and show the safety data sheet of the compound.