4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE

4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE - Names and Identifiers

Name	4-(trifluoromethyl)benzenecarboximidamide hydrochloride (1:1)
Synonyms	4-TrifluoroMethyl-benzanidibe HCL 4-TRIFLUOROMETHYL-BENZAMIDINE HCL 2,6-dichlorobenzenecarboximidamide 4-Trifluoromethylbenzamidinehydrochloridel 4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE 4-(Trifluoromethyl)Benzamidine Hydrochloride 4-(Trifluoromethyl)benzenecarboximidamide hydrochloride 4-(Trifluoromethyl)benzene-1-carboximidamide hydrochloride
CAS	38980-96-0
InChI	InChI=1/C7H6Cl2N2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,(H3,10,11)

4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE - Physico-chemical Properties

Molecular Formula	C8H8ClF3N2
Molar Mass	224.61
Density	1.46g/cm³
Melting Point	158-161℃
Boling Point	287.5°C at 760 mmHg
Flash Point	127.7°C
Vapor Presure	0.00247mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.62

4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37 - Wear suitable protective clothing and gloves.

4-TRIFLUOROMETHYL-BENZAMIDINE HYDROCHLORIDE - Reference Information

Uses

4-trifluoromethylbenzamidine hydrochloride is used as an intermediate in pharmaceutical synthesis.

preparation

the preparation of 4-trifluoromethylbenzamidine hydrochloride is as follows: weigh 85.5g(0.5mol) of 4-trifluoromethylbenzonitrile into a 250mL round bottom flask, add 200mL of methanol to dissolve it, add 5.6g(0.052mol) of methanol solution of sodium methoxide with a mass percentage of 50%, and react by magnetic stirring for 3h at room temperature. After 27.5g(0.515mol) of ammonium chloride was put into the above system, the reaction continued at room temperature for 48h. TLC tracks the end point of the reaction, evaporates the solvent after the reaction is over, the remaining solid is washed with ether, filtered, and repeated three times, the filter cake is in turn with hot water (about 60 ℃), and ethanol is recrystallized to obtain white needle-like crystal 4-trifluoromethylbenzamidine hydrochloride 97g, the yield is 86.4%.

Last Update：2024-04-09 20:52:54

Suzhou Haofan biological Co., Ltd.

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