Name | 4-Hydroxyquinazoline |
Synonyms | 4-Quinazolinol Quinazolone, 4- 4-Quinazolinone 4-Oxoquinazoline 4-HydroxyquinazoL 4(3H)-Quinazolone Hydroxyquinazoline quinazolidin-4-one 1H-quinazolin-4-one 4(3H)-Quinazolinone 4-Hydroxyquinazoline quinazolin-4(3H)-one 4-hydroxy quinazoline Quinazolin-4-ol, 4-Quinazolinol |
CAS | 491-36-1 17227-47-3 |
EINECS | 207-735-8 |
InChI | InChI=1/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11) |
InChIKey | QMNUDYFKZYBWQX-UHFFFAOYSA-N |
Molecular Formula | C8H6N2O |
Molar Mass | 146.15 |
Density | 1.2312 (rough estimate) |
Melting Point | 216-219 °C (lit.) |
Boling Point | 265.75°C (rough estimate) |
Flash Point | 137.3°C |
Water Solubility | Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM). |
Solubility | Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM). |
Vapor Presure | 0.015Pa at 20℃ |
Appearance | White crystal |
Color | Off-white to light beige |
BRN | 118473 |
pKa | 2.69±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month. |
Sensitive | Hygroscopic |
Refractive Index | 1.4900 (estimate) |
MDL | MFCD00511302 |
Physical and Chemical Properties | This product is white crystal, m.p.214 ~ 215 ℃, insoluble in water. |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
WGK Germany | 3 |
RTECS | VA2300000 |
HS Code | 29335995 |
Hazard Class | IRRITANT |
Reference Show more | 1. Liwei He, Fangtian Fan, Xianbang Hou, Hongyan Wu, Juan Wang, Huiqin Xu, Yun Sun, 4(3H)-Quinazolone regulates innate immune signaling upon respiratory syncytial virus infection by moderately inhibiting the RIG-1 pathway in RAW264.7 cell, International Immun |
White needle-like crystals. Molecular weight 146.15, melting point 217~221 C (215~216 C).
obtained by cyclization of anthranilic acid with formamide. The process is to add anthranilic acid and formamide to the stainless steel reaction pot, stir and heat for 4H, maintain the oil bath temperature of 140~150 ℃; Then add cold water under stirring, when the temperature drops below 60 ℃, product
Water was added, stirred evenly, left overnight, filtered, washed with water, washed with alcohol, and dried at 100-120 ° C. To obtain quinazolone with a yield of 80%.
This product is used for the synthesis of antiarrhythmic drug changanthroline.
irritation, LD50 609mg/kg (mouse oral).