4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one - Names and Identifiers
4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one - Physico-chemical Properties
Molecular Formula | C9H9ClN2O
|
Molar Mass | 196.63 |
Density | 1.333±0.06 g/cm3(Predicted) |
Boling Point | 348.6±42.0 °C(Predicted) |
pKa | 0.20±0.20(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one - Introduction
4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one, also known as 4-chloro-2-methyl-quinazolin-6-one, has the chemical formula C10H8ClNO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless or light yellow solid
-Melting point: 165-169°C
-Boiling Point: 319-321°C
-Solubility: Soluble in most organic solvents, such as alcohols and chlorinated hydrocarbons
Use:
-Chemical synthesis: 4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one is commonly used as an organic synthesis intermediate for the synthesis of biologically active compounds.
-Drug research: its derivatives have a broad spectrum of biological activity, including antibacterial, antiviral, anti-tumor and so on. Therefore, the compound and its derivatives have an important position in the field of pharmaceutical research.
Method:
4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one can be synthesized by the following steps:
1. mixing dichloromethane, benzylamine and triethylamine solvent and stirring at room temperature to react to form azaloxane;
2. Add benzaldehyde and dichloroethane solution and continue to stir;
3. Add triethylamine and stir to generate the product;
4. persilicic acid wax treatment, the end of the reaction;
5. The product is crystallized in hydrogen chloride ether to obtain the target compound.
Safety Information:
- 4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one is a combustible solid that may cause combustion when exposed to high temperatures or flames.
-Wear appropriate personal protective equipment such as goggles and gloves during operation.
-Avoid contact with skin, eyes and respiratory system. In case of accidental contact, rinse immediately with plenty of water and seek medical help.
-should be stored away from the fire and oxidant, stored in a dry, cool place.
It should be noted that this is only a basic introduction to 4-Chloro-2-Methyl-7,8-dihydroquinazolin-6(5H)-one. Please learn more about relevant information and guidelines before use to ensure safe operation.
Last Update:2024-04-09 19:05:53