4-Chloro-2-(chlorocarbonyl)pyridine, 4-Chloropicolinoyl chloride
4-Chloro-pyridine-2-carbonyl chloride
CAS: 53750-66-6
Molecular Formula: C6H3Cl2NO
4-Chloro-2-(chlorocarbonyl)pyridine, 4-Chloropicolinoyl chloride - Names and Identifiers
4-Chloro-2-(chlorocarbonyl)pyridine, 4-Chloropicolinoyl chloride - Physico-chemical Properties
| Molecular Formula | C6H3Cl2NO |
| Molar Mass | 176 |
| Density | 1.454±0.06 g/cm3(Predicted) |
| Boling Point | 227.2±20.0 °C(Predicted) |
| Flash Point | 91.218°C |
| Vapor Presure | 0.078mmHg at 25°C |
| pKa | -1.45±0.10(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.566 |
4-Chloro-2-(chlorocarbonyl)pyridine, 4-Chloropicolinoyl chloride - Risk and Safety
| Hazard Note | Corrosive |
4-Chloro-2-(chlorocarbonyl)pyridine, 4-Chloropicolinoyl chloride - Introduction
chloride is an organic compound whose chemical formula is C6H3Cl2NO and is a colorless to pale yellow liquid in appearance.
Nature:
The chloride has a strong pungent odor and high volatility. It is a relatively stable compound, but it reacts with water and decomposes under humid conditions. It is soluble in some organic solvents, such as ether and chloroform.
Use:
The chloride is often used as an acylating reagent in organic synthesis, and it can be activated as an acyl group for the synthesis of various acyl-containing compounds. It can also be used to prepare other organochlorine compounds and is widely used in industries such as pharmaceuticals, pesticides, dyes and cosmetics.
Preparation Method:
The preparation of chloride is usually obtained by reacting 4-chloropyridine with thionyl chloride. First, 4-chloropyridine was dissolved in dichloromethane, thionyl chloride was added, and the reaction was heated. After completion of the reaction, the target product was obtained by distillation and purification steps.
Safety Information:
chloride is an organochlorine compound, which is irritating and corrosive. Wear appropriate protective equipment to avoid contact with skin and eyes. During use and storage, avoid contact with strong oxidants and strong bases to avoid dangerous reactions. At the same time, it should be operated in a well-ventilated place to avoid inhaling vapors in closed spaces. In case of accidental contact or inhalation, emergency measures should be taken immediately and medical help should be sought.
Nature:
The chloride has a strong pungent odor and high volatility. It is a relatively stable compound, but it reacts with water and decomposes under humid conditions. It is soluble in some organic solvents, such as ether and chloroform.
Use:
The chloride is often used as an acylating reagent in organic synthesis, and it can be activated as an acyl group for the synthesis of various acyl-containing compounds. It can also be used to prepare other organochlorine compounds and is widely used in industries such as pharmaceuticals, pesticides, dyes and cosmetics.
Preparation Method:
The preparation of chloride is usually obtained by reacting 4-chloropyridine with thionyl chloride. First, 4-chloropyridine was dissolved in dichloromethane, thionyl chloride was added, and the reaction was heated. After completion of the reaction, the target product was obtained by distillation and purification steps.
Safety Information:
chloride is an organochlorine compound, which is irritating and corrosive. Wear appropriate protective equipment to avoid contact with skin and eyes. During use and storage, avoid contact with strong oxidants and strong bases to avoid dangerous reactions. At the same time, it should be operated in a well-ventilated place to avoid inhaling vapors in closed spaces. In case of accidental contact or inhalation, emergency measures should be taken immediately and medical help should be sought.
Last Update：2024-04-09 21:11:58
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View History
4-Chloro-2-(chlorocarbonyl)pyridine, 4-Chloropicolinoyl chloride
Enzalutamide Impurity 47
dimethyl [[3-[(2-methyl-1-oxoallyl)amino]phenyl]sulphonyl]phosphoramidate
(Z)-hexadec-7-en-1-ol
2',3'-dideoxyadenosine
2-(3-(二甲氨基)苯基)乙酸
2H-2,6-Methanofuro[2,3-c]pyridine(9CI)
(7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid 2-oxo-2-phenylethyl ester
四(五氟苯基)硼酸三苯基甲酯
乙酰-酪氨酸乙酯
Enzalutamide Impurity 47
dimethyl [[3-[(2-methyl-1-oxoallyl)amino]phenyl]sulphonyl]phosphoramidate
(Z)-hexadec-7-en-1-ol
2',3'-dideoxyadenosine
2-(3-(二甲氨基)苯基)乙酸
2H-2,6-Methanofuro[2,3-c]pyridine(9CI)
(7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid 2-oxo-2-phenylethyl ester
四(五氟苯基)硼酸三苯基甲酯
乙酰-酪氨酸乙酯