4-Bromo-7-fluoro-1H-indazole - Names and Identifiers
4-Bromo-7-fluoro-1H-indazole - Physico-chemical Properties
Molecular Formula | C7H4BrFN2
|
Molar Mass | 215.02 |
Density | 1.861±0.06 g/cm3(Predicted) |
Boling Point | 330.3±22.0 °C(Predicted) |
pKa | 10.88±0.40(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
4-Bromo-7-fluoro-1H-indazole - Risk and Safety
4-Bromo-7-fluoro-1H-indazole - Introduction
4-Bromo-7-fluoro-1H-indazole is an organic compound with the chemical formula C7H4BrFN2. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: colorless crystal
-melting point: 97-98 ℃
-Boiling point: 321.6 ℃
-Density: 1.859g/cm3
-Solubility: Soluble in organic solvents such as ethanol, dimethylformamide
-chemical properties: nucleophilic aromatic substitution reaction can occur under alkaline conditions, prone to alkali metal reduction reaction.
Use:
4-Bromo-7-fluoro-1H-indazole has certain applications in the field of medicine:
-As a drug intermediate: It can be used to synthesize biologically active compounds, such as anti-cancer drugs, antiviral drugs, etc.
-as an organic synthesis reagent: can participate in a variety of organic synthesis reaction, expand the chemical toolbox of organic synthesis.
Preparation Method:
There are many preparation methods for 4-bromo-7-fluoro-1H-indazole. The following is one of the commonly used methods:
4-bromoindazole and sodium fluoride are reacted under the catalysis of aminocopper (I) to generate 4-bromo-7-fluoro-1H-indazole.
Safety Information:
-The compound is toxic and should be handled in accordance with laboratory safety procedures, and try to avoid inhalation, contact with skin and eyes.
-During the operation, attention should be paid to protective measures, such as wearing protective glasses, gloves and laboratory clothing, and maintaining good ventilation.
-During use and storage, compounds should be separated from inflammables, oxidants and other substances to avoid dangerous accidents.
-Seek immediate medical attention if you ingest or inhale large amounts of the compound.
Last Update:2024-04-09 02:00:41