Name | 4-Benzyl-2-hydroxy-morpholin-3-one |
Synonyms | -2-hydroxymorphoL Aprepitant Impurity 48 Fosaprepitant Impurity B Fosaprepitant Impurity 23 4-Benzyl-2-hydroxymorpholin-3-one 4-BENZYL-2-HYDROXY-MORPHOLIN-3-ONE 4-Benzyl-2-hydroxy-morpholin-3-one 2-Hydroxy-4-(phenylMethyl)-3-Morpholinone 3-Morpholinone,2-hydroxy-4-(phenylMethyl)- 3-morpholinone, 2-hydroxy-4-(phenylmethyl)- |
CAS | 287930-73-8 |
EINECS | 811-794-0 |
InChI | InChI=1/C11H13NO3/c13-10-11(14)15-7-6-12(10)8-9-4-2-1-3-5-9/h1-5,11,14H,6-8H2 |
Molecular Formula | C11H13NO3 |
Molar Mass | 207.23 |
Density | 1.292±0.06 g/cm3(Predicted) |
Melting Point | 134.0 to 138.0 °C |
Boling Point | 441.7±45.0 °C(Predicted) |
Flash Point | 220.943°C |
Solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
Vapor Presure | 0mmHg at 25°C |
Appearance | Solid |
Color | White to Off-White |
pKa | 11.00±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.595 |
use | for the treatment of depression and chemotherapy-induced vomiting; It can prevent acute and delayed nausea and vomiting caused by the first and subsequent repeated chemotherapy. The key intermediate of aprepitant/aprepitant is |