4-(bromomethyl)-5-phenyl-1,3-oxazole - Names and Identifiers
4-(bromomethyl)-5-phenyl-1,3-oxazole - Physico-chemical Properties
Molecular Formula | C10 H8 Br N O
|
Molar Mass | 238.08 |
Density | 1.485±0.06 g/cm3(Predicted) |
Melting Point | 43-45 |
Boling Point | 351.8±30.0 °C(Predicted) |
Flash Point | 166.552°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 0.01±0.10(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.587 |
4-(bromomethyl)-5-phenyl-1,3-oxazole - Risk and Safety
Risk Codes | R34 - Causes burns
R22 - Harmful if swallowed
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
|
Hazard Note | Corrosive |
4-(bromomethyl)-5-phenyl-1,3-oxazole - Introduction
4-(bromomethyl)-5-phenyl-1,3-oxazole is an organic compound with the chemical formula C10H8BrNO. It has the following properties:
1. Appearance: It is a colorless or light yellow solid.
2. Solubility: It has good solubility in common organic solvents.
The main uses of 4-(bromomethyl)-5-phenyl-1,3-oxazole are as follows:
1. Chemical research: It is often used as an intermediate in organic synthesis reactions, especially in the preparation of phenyl derivatives.
2. drug research: due to its special structure, 4-(bromomethyl)-5-phenyl-1,3-oxazole is often used to synthesize biologically active organic compounds, such as drugs.
The preparation method of 4-(bromomethyl)-5-phenyl-1,3-oxazole can be carried out by the following steps:
1. Synthesis of 2-hydroxyethyl-4-bromobutyrate. This can be obtained by reacting vinylmagnesium bromide with acetic anhydride.
2. Synthesis of 4-(bromomethyl)-5-phenyl-1,3-oxazole. Butyl 2-hydroxyethyl-4-bromoacetate is first reacted with cyanide under basic conditions to give 4-(hydroxymethyl)-5-phenyl -1, 3-oxazole. This is then reacted with methyl iodide under basic conditions to produce 4-(bromomethyl)-5-phenyl-l, 3-oxazole.
In terms of safety information, because it is an organic bromine compound, the following matters need to be paid attention:
1. You must wear appropriate protective equipment such as chemical gloves, goggles, and lab coats.
2. avoid contact with skin and eyes, such as accidental contact, should immediately rinse with plenty of water and seek medical help.
3. Avoid inhaling its vapor or dust, and wear a gas mask if necessary.
4. operation and storage to avoid fire and high temperature.
5. comply with the correct waste disposal methods, do not discharge into the environment.
When carrying out laboratory operations or industrial production, the relevant safety procedures and regulations should be strictly observed.
Last Update:2024-04-09 21:21:28