4-(Trifluoromethyl)indoline is an organic compound with a chemical formula of C9H6F3N and a molecular weight of 183.15g/mol. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: 4-(Trifluoromethyl)indoline is white crystalline or white powder.
-Melting point: about 68-70°C.
-Solubility: Good solubility in common organic solvents.
Use:
- 4-(Trifluoromethyl)indoline can be used as a starting material in organic synthesis for the synthesis of indole compounds.
-In the pharmaceutical field, it is widely used as a drug intermediate, such as for the synthesis of anti-cancer drugs and antiviral drugs.
-Due to its special chemical structure, 4-(Trifluoromethyl)indoline also has potential biological activity and may have antibacterial, anti-inflammatory and antioxidant properties.
Method:
The preparation method of 4-(Trifluoromethyl)indoline is more complicated, and there are two commonly used methods:
1. by trifluoromethylation reaction: the indolin is reacted with a trifluoromethylating reagent, such as sodium trifluoromethanesulfonate or trifluoromethylsodium iodide, etc., to obtain the target product.
2. Through fluorination reaction: Indolin is reacted with a fluorinating reagent (such as trifluoroacetic acid fluoride) under appropriate reaction conditions to form 4-(Trifluoromethyl)indoline.
Safety Information:
- 4-(Trifluoromethyl) The safe operation of indoline in a laboratory environment requires compliance with general chemical safety practices, including wearing protective glasses and gloves to avoid contact with skin and eyes.
-The toxicity and harmfulness of 4-(Trifluoromethyl)indoline is not known due to lack of adequate toxicity data. When using or handling the compound, appropriate precautions should be taken to ensure safe handling.
-The compound should be stored in a dry, well-ventilated place, and away from fire and oxidizing agents.
Please note that the safety data and operating instructions for the relevant chemicals must be studied in detail and followed before any chemical experiments or operations are carried out.