Molecular Formula | C13H11ClFNO |
Molar Mass | 251.68 |
Density | 1.306±0.06 g/cm3(Predicted) |
Melting Point | 78.0 to 82.0 °C |
Boling Point | 387.9±32.0 °C(Predicted) |
Flash Point | 188.4°C |
Vapor Presure | 3.19E-06mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Gray to Red |
pKa | 3.98±0.10(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.607 |
UN IDs | 3077 |
HS Code | 29221990 |
Hazard Class | 9 |
Packing Group | III |
Introduction | 3-chloro-4-(3-fluorobenzyloxy) aniline is an intermediate of lapatinib (lapatinib). Lapatinib is an oral small molecule epidermal growth factor (EGFR:ErbB-1,ErbB-2) tyrosine kinase inhibitor. Lapatinib is used in combination with capecitabine in the treatment of ErbB-2 overexpressed advanced or metastatic breast cancer that has previously received treatment including anthracyclines, paclitaxel and trastuzumab (Herceptin). |