4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride
Sarpogrelate Hydrochloride
CAS: 135159-51-2
Molecular Formula: C24H32ClNO6
4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride - Names and Identifiers
| Name | Sarpogrelate Hydrochloride |
| Synonyms | Anplag ANPLAG MCI9042 MCI 9042 MCI-9042 Sarpogrelate HCL Sarpogrelate.HCl Sarpogrelate-D3 HCl Sarpogrelate Hydrochloride Sarpogrelate Hydrochloride intermediate Butanedioic acid, mono[2-(dimethylamino)-1-[[ 4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride (9CI) Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride, (+-)- |
| CAS | 135159-51-2 |
| EINECS | 663-199-9 |
| InChI | InChI=1/C24H31NO6.ClH/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-4-8-19(22)12-11-18-7-6-9-20(15-18)29-3;/h4-10,15,21H,11-14,16-17H2,1-3H3,(H,26,27);1H |
| InChIKey | POQBIDFFYCYHOB-UHFFFAOYSA-N |
4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride - Physico-chemical Properties
| Molecular Formula | C24H32ClNO6 |
| Molar Mass | 465.96698 |
| Melting Point | 145-148°C |
| Boling Point | 585.9°C at 760 mmHg |
| Flash Point | 308.1°C |
| Solubility | deionized water: ≥5mg/mL |
| Vapor Presure | 1.43E-14mmHg at 25°C |
| Appearance | solid |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD00887582 |
| In vitro study | Sarpogrelate is selective for 5-HT 2 (pK i =7.54) over 5-HT 1 (pK i =4.58), α 1 -, α 2 -, and β-adrenergic (pK i =3.17-6.19), and muscarinic receptors (pK i =4.39). Sarpogrelate (10 μM) significantly reduces the number of platelet-rich plasma (PRP)-induced THP-1 cell that adheres to human umbilical vein endothelial cells (HUVECs). Sarpogrelate (10 μM) significantly reduces the expression of PRP-induced E-selectin in HUVECs. |
4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
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View History
4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride
RARECHEM AL BO 0248
1,4-Bis[1-[2-methoxy-5-(phenylcarbamoyl)phenylazo]-2-hydroxy-3-naphthoylamino]-2,3-dimethylbenzene
115258-10-1
[1,1'-Biphenyl]-4-ol, 2'-fluoro-3-nitro-
5-chloro-2-methoxy-4-(1-tetrazolyl)benzoic acid
Ethanone,1,1'-[1,2-ethanediylbis(6-hydroxy-6-methyl-3-nitro-3,1-cyclohexanediyl)]bis- (9CI)
丁苯酞杂质10
478033-16-8
1199809-30-7
RARECHEM AL BO 0248
1,4-Bis[1-[2-methoxy-5-(phenylcarbamoyl)phenylazo]-2-hydroxy-3-naphthoylamino]-2,3-dimethylbenzene
115258-10-1
[1,1'-Biphenyl]-4-ol, 2'-fluoro-3-nitro-
5-chloro-2-methoxy-4-(1-tetrazolyl)benzoic acid
Ethanone,1,1'-[1,2-ethanediylbis(6-hydroxy-6-methyl-3-nitro-3,1-cyclohexanediyl)]bis- (9CI)
丁苯酞杂质10
478033-16-8
1199809-30-7