4-氨基-2-氟苯硼酸频那醇酯特地唑胺中间体

4-氨基-2-氟苯硼酸频那醇酯特地唑胺中间体 - Names and Identifiers

Name	3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
Synonyms	4-Amino-2-fluorophenylborinic acid pinacol ester 4-Amino-2-fluorophenylboronic acid, pinacol ester 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 3-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)aniline 3-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzenaMine 3-Fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine Benzenamine,3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- (BenzenaMine,3-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- ), 4-AMino-2-fluorophenylboronic acid pinacol ester, (BenzenaMine,3-fluoro-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)- ) 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 2-(4-Amino-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS	819057-45-9
InChI	InChI=1/C12H17BFNO2/c1-11(2)12(3,4)17-13(16-11)9-6-5-8(15)7-10(9)14/h5-7H,15H2,1-4H3

4-氨基-2-氟苯硼酸频那醇酯特地唑胺中间体 - Physico-chemical Properties

Molecular Formula	C12H17BFNO2
Molar Mass	237.08
Density	1.11±0.1 g/cm3(Predicted)
Boling Point	343.6±32.0 °C(Predicted)
Flash Point	161.6°C
Vapor Presure	6.99E-05mmHg at 25°C
Appearance	Crystalline Powder
Color	White to pale brown
pKa	3.22±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.504

4-氨基-2-氟苯硼酸频那醇酯特地唑胺中间体 - Introduction

3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is an organic compound with the chemical formula C13H18BFNO2.

Nature:
-Appearance: Colorless to light yellow solid
-Melting point: about 60-62 ℃
-Solubility: Soluble in many organic solvents, such as ethanol, ether, etc.

Use:
3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline has important application value in organic synthesis and is often used to construct the skeleton of aromatic amines. The compounds can be used as catalysts, reagents and intermediates for the preparation of other organic compounds requiring fluorine and boron groups.

Preparation Method:
the preparation method of 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is relatively complicated and is generally carried out by organic synthesis method. Specific synthetic steps include the reaction of p-phenylenediboronic acid, the fluorination reaction and the hydroxyl alcohol reaction.

Safety Information:
The use of 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline should pay attention to the following matters:
-Because the compound is irritating, you should wear appropriate personal protective equipment, such as protective glasses and gloves.
-Avoid contact with skin, eyes and respiratory tract.
-Storage should be sealed to avoid contact with oxygen.
-When using this compound, it should be operated in a well-ventilated place to avoid inhaling its vapor. If necessary, air extraction shall be carried out.
-In case of accidental inhalation or eye contact, remove to fresh air immediately and wash adequately. If you feel unwell, seek medical help.

Please note that the information provided above is for reference only. Please strictly follow the safety procedures when using this compound.

Last Update：2024-04-10 22:29:15