4,6-dichloro-2-(4-fluorophenyl)-Quinazoline - Names and Identifiers
4,6-dichloro-2-(4-fluorophenyl)-Quinazoline - Physico-chemical Properties
Molecular Formula | C14H7Cl2FN2
|
Molar Mass | 293.12 |
Density | 1.441±0.06 g/cm3(Predicted) |
Boling Point | 321.2±42.0 °C(Predicted) |
pKa | -0.28±0.30(Predicted) |
Storage Condition | 2-8°C |
4,6-dichloro-2-(4-fluorophenyl)-Quinazoline - Introduction
4,6-dichloro-2-(4-fluorophenyl)-Quinazoline is an organic compound with the chemical formula C16H8Cl2FN and a molecular weight of 317.15. It is a white crystal with relatively stable chemical properties.
The compound has the following properties:
1. melting point: about 183-185 degrees Celsius;
2. Boiling point: about 486.3 degrees Celsius;
3. Solubility: It can be dissolved in a variety of organic solvents, such as methanol, ethanol, dimethyl ketone, etc.
4,6-dichloro-2-(4-fluorophenyl)-Quinazoline has certain application value in the field of drug synthesis. As an organic synthetic intermediate, it can be used to synthesize some anticancer drugs or other bioactive compounds.
Methods for the preparation of 4,6-dichloro-2-(4-fluorophenyl)-Quinazoline are generally accomplished by chemical synthesis. Specific steps may vary depending on the purpose and conditions of the study, but common methods include:
1.4-(benzyl) quinazoline was obtained by the reaction of benzyl halogenated hydrocarbon and quinazoline;
2. Then, 4,6-dichloro -2-(benzyl) quinazoline is generated by the reaction of N-benzyl compound and cuprous chloride;
3. Finally, the benzyl group was replaced by 4-fluorophenyl group through a fluorinated tetranitrogen fiber reaction to obtain the final product 4,6-dichloro-2-(4-fluorophenyl)-Quinazoline.
As far as safety information is concerned, any chemical substance should be handled with caution. When exposed to this compound, the following safety procedures should be followed:
1. Wear appropriate personal protective equipment, such as gloves, glasses and lab coats;
2. avoid inhaling the dust or gas of the compound;
3. If you accidentally come into contact with skin or eyes, rinse immediately with plenty of water and seek medical help;
4. Comply with relevant regulations and laboratory safety rules and regulations during use and storage.
Please note that the information provided here is for reference only, and the specific operation should be carried out according to the actual situation and professional guidance.
Last Update:2024-04-09 21:53:21