Name | 4,5',8-Trimethylpsoralen |
Synonyms | TRIOXSALEN TRISORALEN TRIOXYSALEN 4,5',8-Trimethylpsoralen 2',4,8-Trimethylpsoralen 2,5,9-Trimethyl-7H-furo[3,2-g]chromen-7-one 2,5,9-trimethyl-7-furo[3,2-g][1]benzopyranone 2,5,9-Trimethyl-7H-furo(3,2-g)(1)benzopyran-7-one |
CAS | 3902-71-4 |
EINECS | 223-459-0 |
InChI | InChI=1/C14H12O3/c1-7-4-12(15)17-14-9(3)13-10(6-11(7)14)5-8(2)16-13/h4-6H,1-3H3 |
Molecular Formula | C14H12O3 |
Molar Mass | 228.24 |
Density | 1.2196 (rough estimate) |
Melting Point | 229-231°C(lit.) |
Boling Point | 310.05°C (rough estimate) |
Flash Point | 189.1°C |
Solubility | DMSO: soluble |
Vapor Presure | 2.93E-06mmHg at 25°C |
Appearance | powder |
Color | white |
Merck | 14,9735 |
BRN | 221723 |
Storage Condition | -20°C |
Refractive Index | 1.5557 (estimate) |
In vitro study | Trioxsalen (200 nM) plus 365 nm light produce DNA crosslinks but not breaks in mouse L1210 leukemia cells. Trioxsalen/UVA treatment of HaCaT keratinocytes induces NFkappaB binding activity, and that this is a synergistic effect. Trioxsalen shows anti-inflammatory capacities in vitro. |
In vivo study | Trioxsalen induces dose-dependent depletion of ATPase-positive LCs, with a maximal depletion of 80%, in oral mucous membrane (OMM) with PUVA (UVA doses of 1-8 J/cm2) in rat. |
Hazard Symbols | C - Corrosive |
Risk Codes | R34 - Causes burns R40 - Limited evidence of a carcinogenic effect |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
UN IDs | UN 1759 8/PG 1 |
WGK Germany | 2 |
RTECS | LV1576000 |
FLUKA BRAND F CODES | 8-10 |
TSCA | Yes |
HS Code | 29322985 |
Hazard Class | 8 |
Packing Group | III |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.381 ml | 21.907 ml | 43.814 ml |
5 mM | 0.876 ml | 4.381 ml | 8.763 ml |
10 mM | 0.438 ml | 2.191 ml | 4.381 ml |
5 mM | 0.088 ml | 0.438 ml | 0.876 ml |
(IARC) carcinogen classification | 3 (Vol. 40, Sup 7) 1987 |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
biological activity | Trioxsalen (Trisoralen) is a derivative of psoralen. Trioxsalen is a photochemical DNA cross-linking agent that only works when activated by near-ultraviolet light. Trioxsalen is a photosensitizer that can be used in the study of vitiligo and hand eczema. Trioxsalen visualization of cross-linking between genomic strands that can be used for laser-activated localization. |