Name | Desvenlafaxine Succinate |
Synonyms | Pristiq Unii-zb22enf0xr Desvenlafaxine Desvenlafaxine succinate Desvenlafaxine Succinate Desvenlafaxine (succinate hydrate) Desvenlafaxine succinate monohydrate 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate hydrate 4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol succinate monohydrate 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol butanedioate hydrate (salt) 2-(1-Hydroxycyclohexyl)-2-(4-hydroxyphenyl)ethyl]dimethylammonium3-carboxypropanoatemonohydrate |
CAS | 386750-22-7 |
InChI | InChI=1/C16H25NO2.C4H6O4.H2O/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;5-3(6)1-2-4(7)8;/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1-2H2,(H,5,6)(H,7,8);1H2 |
Molecular Formula | C16H25NO2.C4H6O4.H2O |
Molar Mass | 399.48 |
Boling Point | 403.8°C at 760 mmHg |
Flash Point | 193.2°C |
Vapor Presure | 3.03E-07mmHg at 25°C |
Storage Condition | Store at +4°C |
In vitro study | Desvenlafaxine succinate is a succinate monohydrate of O-Desmethylvenlafaxine, an active metabolite of venlafaxine. Desvenlafaxine Succinate is a serotonin-norepinephrine reuptake inhibitor and an active metabolite of the antidepressant venlafaxine. Similar to venlafaxine, Desvenlafaxine Succinate inhibits the neuronal uptake of serotonin and norepinephrine. Desvenlafaxine Succinate showed a weak affinity for the human dopamine (DA) transporter (62% inhibition at 100 μm). Desvenlafaxine Succinate inhibition [Desvenlafaxine Succinate has the potential to inhibit CYP2D6, which may lead to an increase in the concentration of drug metabolism through this pathway. Desvenlafaxine Succinate may also induce CYP3A4, which may affect the metabolism of drugs by this enzyme. |
In vivo study | Desvenlafaxine Succinate rapidly penetrates the brain and hypothalamus of male rats. Desvenlafaxine Succinate significantly increased extracellular NE levels compared to basal NE levels in the hypothalamus of male rats, but did not affect DA levels by microdialysis. Desvenlafaxine Succinate showed a linear dose-proportional pharmacokinetic single-dose distribution over the dose range of 100 to 600 mg/kg. The full bioavailability of the oral dosage form is 80.5%. |
HS Code | 2922504500 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.503 ml | 12.516 ml | 25.033 ml |
5 mM | 0.501 ml | 2.503 ml | 5.007 ml |
10 mM | 0.25 ml | 1.252 ml | 2.503 ml |
5 mM | 0.05 ml | 0.25 ml | 0.501 ml |