Name | 2-Chloro-5-fluorophenol |
Synonyms | 2-Chloro-5-flurophenol 2-Chloro-5-fluorophenol 2-CHLORO-5-FLUOROPHENOL Phenol, 2-chloro-5-fluoro- methyl 2-(trifluoromethyl)prop-2-enoate |
CAS | 3827-49-4 |
EINECS | 609-539-1 |
InChI | InChI=1/C5H5F3O2/c1-3(4(9)10-2)5(6,7)8/h1H2,2H3 |
Molecular Formula | C6H4ClFO |
Molar Mass | 146.55 |
Density | 1.3675 (estimate) |
Boling Point | 183-185 °C |
Flash Point | 183-185°C |
Water Solubility | slightly soluble |
Vapor Presure | 19.5mmHg at 25°C |
Appearance | Liquid |
Color | Clear colorless to pale yellow |
pKa | 7.50±0.10(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.524-1.526 |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed |
Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | 2810 |
HS Code | 29081990 |
Hazard Note | Irritant |
Hazard Class | 8 |
introduction | 2-chloro -5-fluorophenol is a transparent colorless to light yellow liquid with density of 1.408 g/cm3 and boiling point of 183-185 c. Fluorine-containing compounds are one of the most rapidly growing chemicals in the field of fine chemicals, especially the development and application of synthetic methods of aromatic fluorine-containing compounds have received extensive attention from industry and scientific circles at home and abroad. |
use | 2-chloro-5-fluorophenol is a pharmaceutical intermediate that can be used to synthesize a triazole oxytocin anti-sanding agent. |
synthesis method | the synthesis method of 2-chloro-5-fluorophenol has not been publicly reported. In this paper, 2-chloro-5-fluorophenol was synthesized from p-fluoroaniline by bromination, diazotization chlorination and Grignattl reaction. The synthetic route is shown below. Fig. 1 roadmap for synthesis of 2-chloro-5-fluorophenol |