Name | diazoxide |
Synonyms | Sch-6783 Eudemine hyperstat NSC-64198 diazoxide DIAZOXIDE,USP DIAZOXIDE ACTIVATOR OF ATP-DEPE 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 7-chloro-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide 7-chloro-3-methyl-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 7-chloro-3-methyl-1lambda~4~,2,4-benzothiadiazin-1-ol 1-oxide Diazoxide,7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide |
CAS | 364-98-7 |
EINECS | 206-668-1 |
InChI | InChI=1/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11,12,13) |
Molecular Formula | C8H7ClN2O2S |
Molar Mass | 230.67 |
Density | 1.3767 (rough estimate) |
Melting Point | >310°C |
Boling Point | 414.8±47.0 °C(Predicted) |
Water Solubility | Soluble in 0.1M NaOH. Insoluble in water or in methanol. |
Solubility | 0.1 M NaOH: soluble |
Appearance | neat |
Color | White |
Maximum wavelength(λmax) | ['268nm(MeOH)(lit.)'] |
Merck | 14,3004 |
pKa | pKa 8.5 (Uncertain) |
Storage Condition | 2-8°C |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Refractive Index | 1.6300 (estimate) |
Physical and Chemical Properties | White or off-white crystalline powder. Melting point 330-331 °c. Soluble in ethanol, slightly soluble in acetone, chloroform, methanol, insoluble in water, soluble in sodium hydroxide solution. No odor, slightly bitter taste. |
In vitro study | Diazoxide inhibits the inflammatory activity of microglia. In microglia, Diazoxide treatment can partially inhibit the inflammatory pattern induced by LPS/IFN-γ and reduce the production of NO, Diazoxide has NO effect on the phagocytosis of microglia. |
In vivo study | Diazoxide is beneficial for improving cognition, reducing anxiety and stress, reducing the accumulation of amyloid beta protein oligomers, and hyperphosphorylation of tau protein. Diazoxide may exert its neuroprotective effects by reducing neuronal excitability and activating NMDA receptors or by increasing currents through AMPA receptors. Disease severity was reduced in animals treated with Diazoxide. Daily administration of oral Diazoxide to EAE mice (in the disease-effect stage) will reduce the severity of their clinical symptoms without significant side effects. Diazoxide reduces demyelination and axonal loss, reduces and prevents damage, inhibits microglia/macrophage and astrocyte activation, and protects neuronal integrity. No effect on the number of B and T lymphocytes infiltrating the spinal cord. |
Hazard Symbols | Xn - Harmful |
Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | DK8185000 |
HS Code | 2934990002 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.335 ml | 21.676 ml | 43.352 ml |
5 mM | 0.867 ml | 4.335 ml | 8.67 ml |
10 mM | 0.434 ml | 2.168 ml | 4.335 ml |
5 mM | 0.087 ml | 0.434 ml | 0.867 ml |