Name | DL-monosodium glutamate |
Synonyms | Sodium Glutamate Monosodium glutamate Monosodium Glutamate sodium glutamate(1-) sodium acid l-glutamate Monosodium DL-glutamate DL-monosodium glutamate disodium 2-aminopentanedioate Sodium 5-oxido-5-oxonorvaline Glutamic acid, monosodium salt sodium 2-amino-4-carboxybutanoate Glutamic acid, monosodium salt, DL- α-Amiopetandioic acid monosodium salt Monosodium glutamate with other flavour-enhancers |
CAS | 32221-81-1 |
EINECS | 200-533-0 |
InChI | InChI=1/C5H9NO4.Na/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);/q;+1/p-1 |
Molecular Formula | C5H8NNaO4 |
Molar Mass | 169.11109 |
Stability | Stable. Incompatible with strong oxidizing agents |
Physical and Chemical Properties | White prismatic crystal or crystalline powder, odorless, special meat flavor. The relative density is 1.635, the melting point is 195 ° C., and the filling specific volume is 1.20. Soluble in water, 5% aqueous solution PH 6.7-7.2, difficult to dissolve in ethanol and ether. He lost crystal water at 120 ℃, and intramolecularly dehydrated into sodium pyroglutamate at 150-160 ℃, which lost flavor and decomposed into pyrrole at about 270 ℃. Mouse oral LD5016.2g/kg,ADI does not require special provisions (FAO/WHO,1994). |
Use | Used as a food flavoring agent |
Raw Materials | L-Glutamic acid Sodium carbonate Starch potato Charcoal Sulfuric acid Urea Sodium hydroxide Hydrochloric acid Ammonia |
pharmaceutical excipients, flavors and cosolvents.
This product is The monosodium salt of L-2-amino Glutaric acid. The content of C5H8NNa04 • H20 shall be between 99.0% and 100.5% calculated as dry.
take this product, precision weighing, add 2mol/L hydrochloric acid solution to dissolve and quantitatively dilute to make about O in each lml. 1g of the solution was measured according to the law (General rule 0621), and the specific rotation was 24.8 ° to 25.3 °.
take l.Og of this product, Add 10ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 6.7~7.2.
take l.Og of this product, add water 10ml to dissolve, according to UV-visible spectrophotometry (General rule 0401), determine the transmittance at the wavelength of 430mn, not less than 98.0%.
take 0.10g of this product and check it according to law (General rule 0801). Compared with the control solution made of 0.05% of standard sodium chloride solution, it should not be more concentrated ().
take 0.5g of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.03% of standard potassium sulfate solution, it should not be more concentrated ().
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard ammonium chloride solution, it shall not be deeper ().
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 10 mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to scale with water, shake, as a control solution; Take the appropriate amount of sodium glutamate and aspartic acid in the same flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-water-glacial acetic acid (2:1:1) to develop, spread, dry, spray with ninhydrin in acetone solution (1-50), heat at 80°C until spots appear, and immediately inspect. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
take this product, drying at 97~99°C for 5 hours, loss of weight shall not exceed 0.1% (General rule 0831).
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 1.0 ml of standard iron solution, it shall not be deeper (0.001%).
take l.Og of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals not more than 10 parts per million.
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
take this product, check according to law (General 1143), each lg of sodium glutamate containing endotoxin should be less than 25EU. (For injection)
take this product about 80mg, precision determination, add anhydrous formic acid 3ml dissolved, add glacial acetic acid 30ml, according to the potentiometric titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Per 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 9.357mg of C5H8NNao4.H20.
amino acid drugs.
light shielding, sealed storage.
This product is a sterilized aqueous solution of sodium glutamate, or a sterilized aqueous solution made of glutamic acid and an appropriate amount of sodium hydroxide. The content of sodium glutamate (C5H8NNa04) shall be between 95.0% and 105.0% of the labeled amount.
This product is colorless to yellowish clear liquid.
take 15ml of this product, put it in a 50ml measuring flask, add 10ml of hydrochloric acid, dilute it with water to the scale, shake it, determine the optical rotation according to law (General rule 0621), multiply by 11.972, that is, the Weight (g) of the product containing C5H8NNa04 per 100ml.
Same as glutamic acid.
20ml:5.75g
light shielding, closed storage.