Name | nafronyl oxalate |
Synonyms | ls121 eu-1806 CLARANTIN nafronyl oxalate naftidrofuryloxalate Nafronyl acid oxalate Naftidrofuryl oxalate naftidrofuryl hydrogen oxalate 2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionateo 2-(diethylamino)ethyl 3-(naphthalen-1-yl)-2-(tetrahydrofuran-2-ylmethyl)propanoate alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate diethyl-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propanoyl]oxyethyl]ammonium, oxalate diethyl[2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl]ammonium hydrogen oxalate |
CAS | 3200-06-4 |
EINECS | 221-703-0 |
InChI | InChI=1/C24H33NO3.C2H2O4/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20;3-1(4)2(5)6/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3;(H,3,4)(H,5,6)/p-1 |
Molecular Formula | C26H35NO7 |
Molar Mass | 473.56 |
Density | 1.2205 (rough estimate) |
Melting Point | 110-111° |
Boling Point | 574°C (rough estimate) |
Flash Point | 355.6°C |
Solubility | Freely soluble in water, freely soluble or soluble in ethanol (96 per cent), slightly or sparingly soluble in acetone. |
Vapor Presure | 1.48E-18mmHg at 25°C |
Storage Condition | 2-8℃ |
Refractive Index | 1.6000 (estimate) |
In vitro study | Naftidrofuryl oxalate (Nafronyl oxalate salt) may be effective for relieving the pain of muscle cramps. Naftidrofuryl oxalate (Nafronyl oxalate salt) is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective. Naftidrofuryl oxalate (Nafronyl oxalate salt) is ranked first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0·947 and 0·987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate (Nafronyl oxalate salt) is effective treatments for claudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events. |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | 36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | LU5805000 |
HS Code | 29321900 |
Toxicity | LD50 oral in rat: 711mg/kg |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.112 ml | 10.558 ml | 21.117 ml |
5 mM | 0.422 ml | 2.112 ml | 4.223 ml |
10 mM | 0.211 ml | 1.056 ml | 2.112 ml |
5 mM | 0.042 ml | 0.211 ml | 0.422 ml |