Molecular Formula | C5H9ClO |
Molar Mass | 120.58 |
Density | 1.11g/mLat 25°C(lit.) |
Boling Point | 150-151°C(lit.) |
Flash Point | 47 °C |
Solubility | Not miscible or difficult to mix. |
Vapor Presure | 4.88mmHg at 25°C |
Appearance | clear liquid |
Color | Colorless to Light yellow |
BRN | 102716 |
Storage Condition | 2-8°C |
Sensitive | Moisture Sensitive |
Refractive Index | n20/D 1.455(lit.) |
Physical and Chemical Properties | boiling point 150-151°C(lit.) |
Use | Intermediates in organic synthesis. |
Hazard Symbols | Xi - Irritant |
Risk Codes | R10 - Flammable R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S24/25 - Avoid contact with skin and eyes. S16 - Keep away from sources of ignition. |
UN IDs | UN 1993 3/PG 3 |
WGK Germany | 3 |
RTECS | LU0350000 |
FLUKA BRAND F CODES | 21-10 |
TSCA | Yes |
HS Code | 29321900 |
Hazard Class | 3 |
Packing Group | III |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
use | organic synthesis intermediate. |
production method | 2-tetrahydrofuran methanol and pyridine are mixed, stirred and cooled, and thionyl chloride is added dropwise. as the reaction progresses, paste-like substances are precipitated and exothermic to increase the temperature and control the temperature below 60 ℃. Continue to add thionyl chloride dropwise, and the reactant dissolves into a brown-black liquid. After 3-4h of reaction, the reaction solution was extracted with ether. After the ether extract was distilled under reduced pressure, the fraction at 47-48 ℃(2.0kPa) was collected as 2-chloromethyltetrahydrofuran. Yield 73%-75%. |
category | flammable liquid |
toxicity classification | poisoning |
acute toxicity | abdominal cavity-mouse LDL0: 250 mg/kg |
flammability hazard characteristics | flammable; toxic chloride fumes from the fire site |
storage and transportation characteristics | warehouse low temperature, ventilation, drying |
fire extinguishing agent | water, carbon dioxide, dry powder, sand |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |