3-thiazole-5-carboxylic acid

3-thiazole-5-carboxylic acid - Names and Identifiers

Name	2-chloro-4-methylthiazole-5-carboxylic acid
Synonyms	2-Chloro-4-methyl-1 3-thiazole-5-carboxylic acid 2-Chloro-4-methylthiazole-5-carboxylicacid 2-chloro-4-methylthiazole-5-carboxylic acid 2-Chloro-4-methyl-5-thiazolecarboxylic acid 5-thiazolecarboxylic acid, 2-chloro-4-methyl- 5-Thiazolecarboxylic acid, 2-chloro-4-methyl- 2-Chloro-4-methyl-1,3-thiazole-5-carboxylic acid 2-chloro-4-methyl-1,3-thiazole-5-carboxylic acid
CAS	40003-48-3
InChI	InChI=1/C5H4ClNO2S/c1-2-3(4(8)9)10-5(6)7-2/h1H3,(H,8,9)

3-thiazole-5-carboxylic acid - Physico-chemical Properties

Molecular Formula	C5H4ClNO2S
Molar Mass	177.61
Density	1.573
Boling Point	364.4±34.0 °C(Predicted)
Flash Point	174.188°C
Vapor Presure	0mmHg at 25°C
pKa	2.16±0.37(Predicted)
Storage Condition	-20℃
Refractive Index	1.615

3-thiazole-5-carboxylic acid - Introduction

Acid is an organic compound whose chemical formula is C6H4ClNO2S. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: acid is a colorless or light yellow solid.
-Solubility: It is soluble in some organic solvents, such as alcohols and ketones, but insoluble in water.
-Melting point: Its melting point is 118-121°C.

Use:
the acid is often used as an intermediate in organic synthesis. It can be used to synthesize drugs, pesticides and other organic compounds.

Preparation Method:
The synthesis of acid can be carried out through the following steps:
1. In an organic solvent, 2-chlorothiazole and methyl acetone are reacted to generate 2-chloro -4-methyl thiazole.
2.2-chloro -4-methyl thiazole is reacted with chlorocyanic acid to generate 2-chloro -4-methyl thiazole -5-carboxy hydrazone.
3. Use 2-chloro-4-methylthiazole-5-carboxylhydrazone to generate the target product acid.

Safety Information:
Acid is generally relatively safe under normal conditions of use. However, as a chemical, it still has some safety considerations:
-Contact: Avoid contact with skin and eyes as it may cause irritation or injury.
-Inhalation and ingestion: Avoid inhaling the dust or eating it. If inhaled or ingested, seek medical help immediately.
-Storage: It should be stored in a dry, cool, sealed container, away from heat and fire.
-Handling and disposal: When using and handling the compound, follow appropriate safety procedures and dispose of it in accordance with local regulations.

Please note that the safety information is for reference only. Please read the product manual carefully before using the compound and follow the correct laboratory safety operations.

Last Update：2024-04-09 20:45:29