3-amino-1,2,3,4-tetrahydrocarbazol - Names and Identifiers
Name | 3-amino-1,2,3,4-tetrahydrocarbazol
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Synonyms | Intermediate of ramatroban 3-amino-1,2,3,4-tetrahydrocarbazol 3-aMino-1,2,3,4-tetrahydrocarbazole 2,3,4,9-tetrahydro-1H-Carbazol-3-amine 2,3,4,9-Tetrahydro-1H-carbazol-3-amine 1H-Carbazol-3-amine, 2,3,4,9-tetrahydro- TIANFU-CHEM - 3-Amino-1,2,3,4-tetrahydrocarbazol
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CAS | 61894-99-3
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EINECS | 200-528-9 |
InChI | InChI=1/C12H14N2/c13-8-5-6-12-10(7-8)9-3-1-2-4-11(9)14-12/h1-4,8,14H,5-7,13H2 |
3-amino-1,2,3,4-tetrahydrocarbazol - Physico-chemical Properties
Molecular Formula | C12H14N2
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Molar Mass | 186.25 |
Density | 1.191±0.06 g/cm3(Predicted) |
Melting Point | 170-172 °C(Solv: ethanol (64-17-5)) |
Boling Point | 362.5±42.0 °C(Predicted) |
Flash Point | 200.5°C |
Vapor Presure | 0mmHg at 25°C |
pKa | 17.54±0.40(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.677 |
Use | Rametroban Intermediate |
3-amino-1,2,3,4-tetrahydrocarbazol - Introduction
3-amino-1,2,3,4-tetrahydrocarbazol is an organic compound with the chemical formula C12H14N2. It is a colorless crystalline solid, soluble in common organic solvents, such as ethanol, methanol and dimethylformamide. It is stable in air, but may decompose at high temperatures.
3-amino-1,2,3,4-tetrahydrocarbazol has a wide range of applications in the field of medicine. It is an important intermediate for the synthesis of biologically active compounds, such as drugs and dyes. Common applications include the synthesis of anti-tumor drugs, antidepressants, and neuroprotective agents.
3-amino-1,2,3,4-tetrahydrocarbazol can be prepared by various methods. The most common method is to use carbazolone as the starting material, through the reduction reaction and ammonia dehydration reaction to obtain the target product. Other synthetic methods include the ring expansion reaction of carbazole ring and the cyclization reaction of carbamate and acetophenone.
Regarding safety information, 3-amino-1,2,3,4-tetrahydrocarbazol is relatively stable under routine operation, but it is still necessary to prevent it from contacting skin and eyes. During operation, wear appropriate protective gloves and goggles to ensure a well-ventilated laboratory environment. At the same time, contact with oxidizing agents and strong acids should be avoided to prevent possible dangerous reactions. When stored, it should be kept under dry, low temperature and dark conditions. If necessary, refer to the relevant safety data sheets and operating instructions.
Last Update:2024-04-09 21:11:58