3-AMINO-2-CHLOROPYRIDINE FOR SYNTHESIS
3-Amino-2-chloropyridine
CAS: 6298-19-7
Molecular Formula: C5H5ClN2
3-AMINO-2-CHLOROPYRIDINE FOR SYNTHESIS - Names and Identifiers
| Name | 3-Amino-2-chloropyridine |
| Synonyms | Nsc 45407 AKOS MSC-0729 3-AMINOCHLOROPYRIDINE 3-Amino-2-Chlorpyridine 2-Chloro-3-pyridinamine 2-chloro-3-pyridylamine 2-CHLORO-3-PYRIDYLAMINE 2-chloropyridin-3-amine 3-Amino-2-chloropyridine 2-Chloro-3-aminopyridine 2-CHLORO-3-AMINOPYRIDINE 2-Chloro-3-pyridineaMine 3-AMINO-2-CHLOROPYRIDINE 2-chloro-3-pyridine amine 3-2-chlorine pyridine acetaminophen 3-AMINO-2-CHLOROPYRIDINE FOR SYNTHESIS |
| CAS | 6298-19-7 |
| EINECS | 228-572-9 |
| InChI | InChI=1/C5H5ClN2/c6-5-4(7)2-1-3-8-5/h1-3H,7H2 |
| InChIKey | MEQBJJUWDCYIAB-UHFFFAOYSA-N |
3-AMINO-2-CHLOROPYRIDINE FOR SYNTHESIS - Physico-chemical Properties
| Molecular Formula | C5H5ClN2 |
| Molar Mass | 128.56 |
| Density | 130 |
| Melting Point | 76-78 °C (lit.) |
| Boling Point | 130-134 °C (12.7517 mmHg) |
| Flash Point | 185 °C |
| Water Solubility | Soluble in methanol and water. (30 g/L). |
| Solubility | 30g/l |
| Vapor Presure | 0.0107mmHg at 25°C |
| Appearance | White solid |
| Color | Off-white to yellow to pink |
| BRN | 109814 |
| pKa | 2.42±0.10(Predicted) |
| PH | 7 (30g/l, H2O, 20℃) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5110 (estimate) |
| MDL | MFCD00006238 |
| Physical and Chemical Properties | Density 1.30 melting point 77-82°C boiling point 130-134°C (17 torr) flash point 185°C |
3-AMINO-2-CHLOROPYRIDINE FOR SYNTHESIS - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | UN2811 |
| HS Code | 29333999 |
| Hazard Class | IRRITANT |
3-AMINO-2-CHLOROPYRIDINE FOR SYNTHESIS - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Use | 3-amino-2-chloropyridine is used as a reactant of aryl isoindolinediones for the synthesis of anticonvulsants, it is the key intermediate of two kinds of compounds: chlorbenzamide and pirenzepine, and has broad market prospects |
| preparation | 3-aminopyridine 188g(2mol) was dissolved in 10% hydrochloric acid: 900g (content 10%,2.46mol), after completely dissolving and mixing, the volume ratio of the solution to dichloromethane: 10% G, sodium hypochlorite solution: 1.07g (content, mol) is taken as the preset volume ratio per unit time, then according to the unit Time Volume ratio at room temperature (the temperature of the specific temperature range is 10 ℃-30 ℃) the three were simultaneously and continuously pumped into the first stage extraction centrifuge for extraction centrifugation; After that, the organic phase and the aqueous phase were separated, and the organic phase was retained, and the aqueous phase, industrial hydrochloric acid: 59g (content 31%,0.5mol), Dichloromethane: 200g, And sodium hypochlorite solution: 10% G (content 0.54, mol) four volume ratio as the preset unit time volume ratio, then according to the unit Time Volume ratio at room temperature, the four were respectively and simultaneously continuously pumped into the second stage extraction centrifuge for extraction centrifugation; After that, the organic phase and the aqueous phase were separated, and the organic phase was retained, and put the water phase into the next stage of extraction centrifuge; The amount of hydrochloric acid, methylene chloride and sodium hypochlorite solution used in each stage of the subsequent extraction centrifuge is halved step by step, A total of five stages of continuous extraction reaction (each stage of extraction centrifugal reaction time was 3H), and then the combined organic phase was 3-amino-2-chloropyridine solution; A total of 962G of solution was obtained. Using liquid chromatography, external standard method analysis, external standard method to calculate the content of 24.4%, converted 3-amino-2-chloropyridine weight: 234.5g, the molar yield of 3-amino-2-chloropyridine was 91.3% based on 3-aminopyridine, and the purity was 98.4%. |
Last Update：2024-04-09 15:16:52
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View History
3-AMINO-2-CHLOROPYRIDINE FOR SYNTHESIS
Cis-3-(Boc-Amino)Cyclohexanecarboxylic Acid
三丁基(三甲基甲硅烷基乙炔基)锡
磺甲基酚醛树脂(SMP)、磺化甲基苯酚与甲醛的聚合物
哌啶-4-基硼酸
初馏金缕梅油
等效-6,11-二羟基-15-氧代-16-贝壳杉烯-19-酸 BETA-D-吡喃葡萄糖酯
2,5-二碘吡啶
VASOPRESSIN METABOLITE NEUROPEPTIDE
2-[(2-氰基乙酰基)氨基]噻吩-3-羧酸甲酯
Cis-3-(Boc-Amino)Cyclohexanecarboxylic Acid
三丁基(三甲基甲硅烷基乙炔基)锡
磺甲基酚醛树脂(SMP)、磺化甲基苯酚与甲醛的聚合物
哌啶-4-基硼酸
初馏金缕梅油
等效-6,11-二羟基-15-氧代-16-贝壳杉烯-19-酸 BETA-D-吡喃葡萄糖酯
2,5-二碘吡啶
VASOPRESSIN METABOLITE NEUROPEPTIDE
2-[(2-氰基乙酰基)氨基]噻吩-3-羧酸甲酯