3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE
ABC294640
CAS: 915385-81-8
Molecular Formula: C23H25ClN2O
3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE - Names and Identifiers
3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE - Physico-chemical Properties
| Molecular Formula | C23H25ClN2O |
| Molar Mass | 380.91 |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | ABC294640 significantly altered the ceramide/S1P ratio in MDA-MB-231 cells, consistent with inhibition of SK activity. ABC294640 inhibits tumor cell proliferation with IC50 values ranging from approximately 6 -48 μm and impairs tumor cell migration with loss of microfilaments. In A- 498,PC-3, and MDA-MB-231 cells, ABC294640 induces nonapoptotic cell death, lysosomal morphological changes, autophagosome formation, and increased acid vesicles. ABC294640 reduces e2-stimulated ERE luciferase activity in MCF-7 and ER-transfected HEK293 cells. |
| In vivo study | In mice bearing breast cancer xenografts, ABC294640 (100 mg/kg, p.o.) significantly reduced tumor growth in association with depletion of S1P levels. In severe combined immunodeficient mice bearing A- 498 xenografts, ABC294640 prolongs tumor growth and increases autophagy markers. ABC294640 prevents liver transplantation-induced inflammation and crosstalk between innate and acquired immunity, major substance precipitation and worsening of transplant injury, and improves liver function and survival rate. |
3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.625 ml | 13.126 ml | 26.253 ml |
| 5 mM | 0.525 ml | 2.625 ml | 5.251 ml |
| 10 mM | 0.263 ml | 1.313 ml | 2.625 ml |
| 5 mM | 0.053 ml | 0.263 ml | 0.525 ml |
Last Update：2024-01-02 23:10:35
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View History
3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE
Met-Enkephalin-Arg-PheMERF
4-(CHLOROMETHYL)-2-METHYLTHIAZOLE HCL
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2-甲氧基苯基乙基溴
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Met-Enkephalin-Arg-PheMERF
4-(CHLOROMETHYL)-2-METHYLTHIAZOLE HCL
7-METHYL-alpha-TETRALONE
2-氨基-环丙烷乙酸
4-Hydroxy-7-methoxy-6-quinolinecarboxylic acid
1-(3-AMinopyrrolidin-1-yl)ethanone hydrochloride
Ramifenazone hydrochloride
2-甲氧基苯基乙基溴
METHYL 6-CHLORO-1H-BENZO[D]IMIDAZOL-2-YLCARBAMATE