3-((叔丁氧羰基)氨基)-4-(羟甲基)吡咯烷-1-羧酸苄酯

3-((叔丁氧羰基)氨基)-4-(羟甲基)吡咯烷-1-羧酸苄酯 - Names and Identifiers

Name	3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine
Synonyms	3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine 1-Pyrrolidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-(hydroxymethyl)-, phenylmethyl ester
CAS	1255099-67-2

3-((叔丁氧羰基)氨基)-4-(羟甲基)吡咯烷-1-羧酸苄酯 - Physico-chemical Properties

Molecular Formula	C18H26N2O5
Molar Mass	350.40944
Density	1.22±0.1 g/cm3(Predicted)
Boling Point	510.5±50.0 °C(Predicted)
pKa	12.01±0.40(Predicted)
Storage Condition	2-8°C

3-((叔丁氧羰基)氨基)-4-(羟甲基)吡咯烷-1-羧酸苄酯 - Upstream Downstream Industry

Downstream Products

6-BOC-3,6-DIAZABICYCLO[3.2.0]HEPTANE

3-((叔丁氧羰基)氨基)-4-(羟甲基)吡咯烷-1-羧酸苄酯 - Introduction

3-(N-tert-butoxycarbonyl)amino-4-hydroxymethyl-N-benzyloxycarbonylpyrrolidine is an organic compound with the following properties:

1. Appearance: white crystalline solid
2. Molecular formula: C17H24N2O5
3. Molecular weight: 340.38g/mol
4. Melting Point: 95-102 ° C
5. Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dichloromethane

The compound is commonly used in pharmaceutical synthesis and organic synthesis. It is an important protecting group that can be used to protect amino and hydroxyl groups to avoid non-selective reactions during the reaction. It can be used as an intermediate in the pharmaceutical field to synthesize various bioactive molecules. In addition, it can also be applied to the synthesis of functional compounds and heterocyclic compounds.

The method for preparing the compound is as follows: 3-carboxycaprolactone is obtained by reacting hydroxymethylpyrrolidine with caprolactone in the presence of sodium 3-cyanopropionate. 3-carboxycaprolactone is reacted with tert-butoxycarbodiimide and a sodium salt of an organic base to give tert-butoxycarbonylcaprolactone. Then, tert-butoxycarbonylcaprolactone is reacted with methanol and HCl or H2SO4 to produce tert-butanol hydrochloride. Finally, the target compound is produced by reacting tert-butanol hydrochloride with methylbenzylamine.

For safety information about this compound, the following matters need to be noted:
1. When handling and handling the compound, wear appropriate protective gloves and glasses to avoid contact and inhalation.
2. The compound may be irritating and damaging to the eyes, skin and respiratory system.
3. When storing and handling the compound, follow safe operating procedures and keep away from open flames and high temperatures.
4. When using the compound in the laboratory, ensure that the operating environment is well ventilated.

Last Update：2024-04-09 21:00:56