Name | 3,3',5-triiodo-L-thyronine |
Synonyms | cytomel liothyronine l-liothyronine Triiodothyronine L-triiodothyronine 3',5-triiodo-l-thyronin 3,3',5-triiodothyronine 3,5,3'-triiodothyronine 3,3',5-triiodo-L-thyronine L-3,3,5-Triiodothyronine, Free Acid O-(4-hydroxyphenyl)-2,3,5-triiodotyrosine O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine 4-(3-iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine 5-diiodophenyl)-3-(4-(4-hydroxy-3-iodophenoxy)-l-alanin l-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine |
CAS | 6893-02-3 |
EINECS | 229-999-3 |
InChI | InChI=1/C15H12I3NO4/c16-10-5-7(6-11(19)15(21)22)12(17)13(18)14(10)23-9-3-1-8(20)2-4-9/h1-5,11,20H,6,19H2,(H,21,22) |
Molecular Formula | C15H12I3NO4 |
Molar Mass | 650.97 |
Density | 2.387g/cm3 |
Melting Point | 234-238℃ |
Boling Point | 602.051°C at 760 mmHg |
Flash Point | 317.909°C |
Solubility | 5 mg/mL, 4M NH4OH in MeOH |
Vapor Presure | 0mmHg at 25°C |
Appearance | White to white-like powder |
Storage Condition | -20℃ |
Refractive Index | 1.763 |
MDL | MFCD00002593 |
Hazard Symbols | Xi - Irritant |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
Reference Show more | 1. Zhou Yamin, Xiao Rong, Hu Yuzhen, etc. Metabolomics study of Polygonatum odoratum polysaccharide on hyperthyroidism Yin deficiency rats [J]. Chinese Pharmaceutical Journal, 2017(14):68-73. 2. Shan, Tong, et al. "Proteomics-Based Mongolian Medicine Modified Sugmul-7 Mechanism of regulatory Endocrine Function in Hyperplasia of the Breast." Clinical Medicine Research 9.1 (2020): 11.doi: 10.11648/j.cmr.20200901.13 3. [IF=4.379] Huo Xiaoqian et al."Discovery of Novel Multi-target Inhibitor of angiotensin type 1 receptor and neprilysin inhibitors from Traditional Chinese Medicine."Sci Rep-Uk. 2019 Nov;9(1):1-10 |
from tyrosine iodinated to 3,5-= iodotyrosine, then acylated with acetic anhydride and condensed with p-methoxybromoiodine anchor, the complex was hydrolyzed, Iodinated, the salt is obtained.
for severe chronic thyroid deficiency (myxedema), cretinism, can also be used as a diagnostic agent for thyroid function.