Fmoc-(R)-3-Amino-5-hexenoic acid is an organic compound with the chemical formula C19H19NO4. It has the following properties:
1. Appearance: White crystalline solid.
2. Solubility: Soluble in some organic solvents, such as methanol, ethanol, dimethylformamide, etc.
3. Melting point: about 140-142°C.
The main use of Fmoc-(R)-3-Amino-5-hexenoic acid is as a protecting group in peptide synthesis in chemical synthesis to protect the active group of amino acids. It can protect the carboxyl group or amino group by Fmoc, and at the same time has the effect of increasing the solubility and stability of the polypeptide. In the process of synthesizing peptides and proteins, it can be used for purification, structural analysis and biological activity research.
The preparation of Fmoc-(R)-3-Amino-5-hexenoic acid is usually obtained by chemical synthesis methods. A common synthetic method is to react Fmoc-protected aminoglutaric acid with an appropriate reagent (such as di (tert-butoxy) acetic acid, DIPEA) to produce Fmoc-(R)-3-Amino-5-hexenoic acid.
For safety information, Fmoc-(R)-3-Amino-5-hexenoic acid may cause irritation to the eyes, skin, and respiratory system. Appropriate laboratory safety practices, such as wearing protective glasses, gloves and face masks, should be used to ensure good ventilation when handling the compound. If you come into contact with this compound, immediately flush the affected area with plenty of water and seek medical help. Specific safety operations should be referenced in accordance with the safety data sheets of the chemical.