Fmoc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid is an organic compound, which has the following properties and uses:
Nature:
1. Chemical formula: C22H19F3NO4
2. Molecular weight: 421.39 grams/mol
3. Appearance: white or white powder
4. Melting point: 137-143°C
5. Solubility: Soluble in organic solvents such as dimethyl sulfoxide and dichloromethane, almost insoluble in water.
Use:
1. Fmoc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid is a commonly used amino acid derivative, which is commonly used in peptide synthesis and drug research in solid phase synthesis.
2. As a protecting group, it can protect the amino group of amino acid and avoid unnecessary reaction in the process of synthesis.
Preparation Method:
The preparation of Fmoc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid can be accomplished by a multi-step reaction. A common synthetic route involves the following steps:
1. The fluorinated trifluoromethylphenylmethane reacts with bromobutyric acid to generate 3-bromo-phenyl-(3-trifluoromethylphenyl) propionic acid.
2.3-Bromo-phenyl-(3-trifluoromethylphenyl) propionic acid is reacted with imidazole in diethyl carbonate to generate an imidazole activator.
3. The imidazole activator reacts with Fmoc-3-aminobutyric acid to generate the target product Fmoc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid.
Safety Information:
1. Fmoc-(R)-3-Amino-4-(3-trifluoromethyl-phenyl)-butyric acid has limited toxicity data, but its chemicals are potentially irritating and dangerous. Please follow correct laboratory practices.
2. during operation and storage, contact with strong oxidants, strong acids or strong bases should be avoided.
3. in the use of the process, should wear appropriate protective gloves, glasses and protective clothing.
Please note that before using any chemical substance, please read and understand the safety data sheet (SDS) of the chemical, and operate under suitable laboratory conditions.