Fmoc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is an organic compound, Fmoc in its name denotes a methylcarbonylpropionyl protecting group. Its chemical formula is C22H19F3NO4 and its molecular weight is 415.39g/mol.
Fmoc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid is widely used in the research and preparation of peptide drugs in solid phase synthesis. It is mainly used as an activated amino acid and can undergo condensation reactions with other amino acids to construct polypeptide chains of specific sequences. At the same time, it can also be used as a chiral inducer for the synthesis of chiral compounds.
The preparation method of the compound is generally obtained by a chemical synthesis step. Specifically, first, 3-propylamino-4-phenylbutyric acid is reacted with trifluoromethylbenzonitrile to produce the target compound. Next, the product is protected to introduce an Fmoc protecting group to the amino group of the target compound.
Regarding safety information, Fmoc-(R)-3-Amino-4-(2-trifluoromethyl-phenyl)-butyric acid may be toxic to the human body, so it is necessary to take appropriate protection during operation. Measures include protective gloves and goggles, and operate in a well-ventilated place. In addition, to avoid contact with skin and eyes, such as accidental contact, should immediately rinse with water. When storing and handling the compound, care should be taken to prevent it from coming into contact with oxygen or moisture, so as not to cause unnecessary reactions.