Fmoc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric is an organic compound commonly used in peptide synthesis and modification in solid-phase synthesis.
Properties Fmoc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric acid is a white crystalline solid. It is insoluble in water, but readily soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), dimethylformamide (DMF) and methanol. Its molecular formula is C21H21NO3 and its molecular weight is 335.4g/mol.
Fmoc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric acid is often used as a protecting group of peptide chain in solid phase synthesis, and is connected to the amino terminal to prevent unnecessary reaction of peptide chain. During the synthesis of the peptide, it can be linked to other amino acid residues through an amino carboxylation reaction, thereby extending the amino acid sequence. In addition, it can also be used to modify peptide chains, for example to introduce specific reactive groups or fluorescent labels.
In terms of preparation, Fmoc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric acid is usually synthesized by chemical synthesis. The specific method is to (R)-3-amino -4-(2-methylphenyl) butyric acid as the starting material, first the Fmoc protecting group is attached to the amino end, and then the synthesis is carried out through a series of chemical reactions.
in terms of safety information, Fmoc-(R)-3-Amino-4-(2-methyl-phenyl)-butyric acid should be operated according to chemical safety operation procedures. It may cause irritation to the eyes, skin and respiratory system. Wear appropriate personal protective equipment, such as lab gloves and glasses. In addition, the compounds should be avoided from inhalation or ingestion and stored in a sealed manner to prevent contact with air or moisture. Specific safety instructions and handling methods can be found in the safety data sheet of the compound.