Name | senegenin |
Synonyms | SENEGIN senegenin SENEGENIN Tenuigenin 12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid 28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2 12α-(Chloromethyl)-2β,3β-dihydroxy-27-nor-5α-olean-13-ene-23,28-dioic acid 27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2,3-dihydroxy-, (2β,3β,4α,12α)- 13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid 13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydropicene-4,8a(1H)-dicarboxylic acid |
CAS | 2469-34-3 |
InChI | InChI=1/C30H45ClO6/c1-26(2)10-11-30(25(36)37)9-6-17-22(18(30)13-26)16(15-31)12-21-27(17,3)8-7-20-28(21,4)14-19(32)23(33)29(20,5)24(34)35/h16,18-21,23,32-33H,6-15H2,1-5H3,(H,34,35)(H,36,37) |
Molecular Formula | C30H45ClO6 |
Molar Mass | 537.13 |
Density | 1.28 |
Melting Point | 290-292℃ |
Boling Point | 674.1±55.0 °C(Predicted) |
Specific Rotation(α) | D +19° (c = 0.70 in ethanol) |
Flash Point | 361.5°C |
Solubility | Generally soluble in water, methanol and dilute ethanol, soluble in hot water, hot methanol and hot ethanol, insoluble in ether, chloroform and benzene. |
Vapor Presure | 4.64E-21mmHg at 25°C |
Appearance | White crystalline powder |
Color | white to beige |
pKa | 4.27±0.70(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.591 |
MDL | MFCD00466906 |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Polygala tenuifolia. |
In vivo study | Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S. aureus -induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice. |
WGK Germany | 3 |
RTECS | RC8815000 |
Toxicity | LD50 intraperitoneal in mouse: 3mg/kg |
Reference Show more | 1. Wen Wen Wang Yu. Effects of Aβ25-35 on SOD and MDA in vitro induced hippocampal neurons and the combination of effective components of Acorus calamus and Polygala [J]. Chinese Medicine Emergency 2012 21(08):1256-1258. |
biological activity | Tenuigenin is the main active ingredient isolated from the root of Chinese herbal medicine Polygala (Polygala tenuifolia). Tenuigenin prevent staphylococcus aureus-induced pneumonia by inhibiting NF-κB activation. |
use | Polygala sapogenin has the functions of improving intelligence and calofor, relieving cough and eliminating phlegm. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has the effects of improving intelligence and calending nerves, relieving cough and eliminating phlegm. Modern pharmacological research has also found that it has hypoglycemic and immune enhancement activities. |