Molecular Formula | C10H9NaO4 |
Molar Mass | 216.17 |
Boling Point | 372.3°C at 760 mmHg |
Flash Point | 150.5°C |
JECFA Number | 2014 |
Solubility | H2O : 100 mg/mL (462.60 mM; Need ultrasonic);DMSO : 33.33 mg/mL (154.18 mM; Need ultra |
Vapor Presure | 3.34E-06mmHg at 25°C |
Appearance | Light yellow powder |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
MDL | MFCD00075727 |
Use | For the treatment of coronary heart disease, ischemic encephalopathy, leukopenia and thrombocytopenia and other conditions |
Reference Show more | 1. Cao Bo, Ci Zhimin, Xu Runchun, et al. Study on Quality Evaluation of Xiaojin Pills Based on Antiplatelet Aggregation Titer [J]. Chinese Herbal Medicine, 2020, v.51;No.664(05):168-173. 2. Zhao Yuling, Hua Fang, Li Guan, et al. Quantitative Determination of Antigel Activity of Chuanxiong and Its Chinese Patent Medicine [J]. Chinese Herbal Medicine, 2020. 3. Hua Fang, zhao Yuling, Li Guan, et al. Study on Determination of Anticoagulant Effect of Ligusticum wallichii and Its Chinese Patent Medicine [J]. Chinese Herbal Medicine, 2019, 50(07):1698-1702. 4. Yao Yixin. Study on Bioassay Methodology of Anti-platelet Aggregation Activity of Ligusticum wallichii, decoction pieces and Chinese Patent Medicine [J]. Chinese Herbal Medicine, 2017, 48(11):2249-2254. 5. Gong Wan, Chen Xiaoling, et al.. Protective effect and mechanism analysis of sodium ferulate on inflammatory injury caused by cerebral ischemia-reperfusion in rats [J]. Chinese Journal of Experimental Formulas, 2019, 25(03):102-107. 6. Xin, Pan Yuan, Xie Xiaofang, Tang Guangmei, Peng Cheng. Effects of anisodine hydrobromide on hemorheology, microcirculation and platelet aggregation [J]. Chinese patent medicine, 2020,42(09):2438-2445. 7. Qiao Mingming, Xiong Liang, Liu Yu, Guo Li, Liu Fei, Peng Cheng. Material Basis Study on Difference of Activating Blood Effect between Turmeric and Curcuma Rhizoma [J]. World Science and Technology-Modernization of Traditional Chinese Medicine, 2020,22(07):2531-2539. |
This product is 3-methoxy-4-hydroxycinnamic acid sodium salt dihydrate. The content of C10H9Na04, calculated as anhydrous, shall not be less than 98.5% (for oral administration) or 99.0% (for injection).
operation in the dark. Take this product, precision weighing, add water to dissolve and quantitatively dilute the solution containing about 10% per lml, according to UV-visible spectrophotometry (General 0401), the absorbance was measured at a wavelength of 310mn, and the absorption coefficient of C10H3NaO4 was 690 to 732.
take this product, add water to make a solution containing about 50mg per lml, check according to law (General 0631), pH value should be 6.0~7.5.
take this product and add water to make a solution containing about 20mg per 1 ml, the solution should be clear and colorless; If the color is colored, compare with the yellow or yellow-green 2 Standard Colorimetric solution (General rule 0901 first method), not deeper (for injection).
operation in the dark. Take this product, add mobile phase to dissolve and dilute to make a solution containing about 0.7mg per 1ml as a test solution; Take 1ml for precision measurement, put it in a 200ml measuring flask, dilute to the scale with mobile phase, as a control solution. According to high performance liquid chromatography (General rule 0512) test, silica gel bonded with eighteen alkyl silane was used as filler; Methanol-water-acetic acid (30:69:1.5) was used as mobile phase; Detection wavelength was 322nm; the number of theoretical plates shall not be less than 2000 calculated by sodium ferulate peak, and the separation degree between sodium ferulate peak and adjacent impurity peak shall meet the requirements. 10 u1 of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 2.5 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (0.5%).
take this product, according to the moisture determination method (General 0832 first method 1), the moisture content should be 13.0% ~ 15.5%.
take this product, add Sterile Water for Injection to make a solution containing 5mg of sodium ferulate per lml, check according to law (General rule 1142), dose according to rabbit body weight per lkg slow injection of 3ml, should meet the requirements. (For injection)
take this product, dissolve it with appropriate solvent, and treat it by membrane filtration method. Check it according to law (General rule 1101). (For aseptic dispensing)
operation in the dark. Take about 0.15g of this product, precision weighing, add glacial acetic acid 20ml to dissolve, add acetic anhydride 3ml and crystal violet indicator solution 1 drop, with perchloric acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 21.62mg of C10H9Na04.
Anti-platelet aggregation drugs.
light shielding, sealed storage.
This product contains sodium ferulate (C10H9Na04 • 2H20) should be 90.0% ~ 110.0% of the label amount.
This product is white or off-white.
operation in the dark. Take 20 tablets of this product, precision weighing, Institute of Precision weighing take appropriate amount (about 50mg equivalent to sodium ferulate), put 250ml measuring bottle, add appropriate amount of water, shake to dissolve sodium ferulate, dilute with water to scale, shake, filter, take the filtrate 5ml accurately, put it in a 100ml measuring flask, dilute it with water until the scale, and shake it well, according to UV-visible spectrophotometry (General rule 0401), the absorbance was measured at a wave of 310nm, calculated with an absorption coefficient of C10H9Na04 of 712 and multiplied by 1.167.
Same as sodium ferulate.
50mg
light shielding, sealed storage.
This product is sterile powder or sterile lyophilized product of sodium ferulate. The content of sodium ferulate (C10H9Na04 • 2H20) shall be 90.00.0% of the label load calculated on average.
This product is white or off-white crystal or crystalline powder (for bacterial powder or white to light yellow or light yellow green loose lumps or powder (for sterile lyophilized products); Odorless.
take this product, according to the sodium ferulate Item Identification (1), (3) test showed the same reaction.
operation in the dark. Take about 0.15g of the content under the item of load difference, weigh it precisely, add 20ml of glacial acetic acid to dissolve sodium ferulate, and start from "add 3ml of acetic anhydride" according to the method under the item of sodium ferulate, determination according to law. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 25.22mg of C10H9Na04 · 2H20.
Same as sodium ferulate.
(1)0.lg (2)0.3g
light shielding, sealed storage.