Name | trimethoprim lactate |
Synonyms | Lactic triMethopriM trimethoprim lactate Trimethoprim lactate salt 5-(3,4,5-Trimethoxybenzyl) pyrimidine-2,4-diamine 2-hydroxypropanoate 2,4-DIAMINO-5-(3,4,5-TRIMETHOXYBENZYL)PYRIMIDINE LACTATE 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine Lactate salt 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt 5-(3,4,5-triMethoxybenzyl)pyriMidine-2,4-diaMine 2-hydroxypropanoate |
CAS | 23256-42-0 |
EINECS | 245-533-1 |
InChI | InChI=1/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6) |
Molecular Formula | C17H24N4O6 |
Molar Mass | 380.4 |
Melting Point | 170 - 172°C |
Boling Point | 526°C at 760 mmHg |
Flash Point | 271.9°C |
Water Solubility | Soluble in water |
Solubility | H2O: soluble20mg/mL |
Vapor Presure | 3.74E-11mmHg at 25°C |
Appearance | White to light yellow powder |
Color | white |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
MDL | MFCD00171722 |
In vitro study | Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF). Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability. |
In vivo study | In intraperitoneal infections in mice, the CD 50 values for Trimethoprim alone against H. influenzae , S. pneumoniae , E. coli and N. meningitidis , is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively. |
Hazard Symbols | T - Toxic |
Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R43 - May cause sensitization by skin contact R61 - May cause harm to the unborn child |
Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. |
UN IDs | UN 2811 |
WGK Germany | 3 |
Hazard Class | 6.1(b) |
Packing Group | III |
biological activity | Trimethoprim lactic is an antibacterial antibiotic and a dihydrofolate reductase (dihydrofolate reductase) inhibitor with oral activity. Trimethoprim lactis are active against a variety of Gram-positive and Gram-negative aerobic bacteria (Gram-positive and Gram-negative aerobic bacteria). Trimethoprim lactic can be used in the study of urinary tract infection, shigellosis and pneumocystis pneumonia. |
target | Dihydrofolate reductase Bacteria |