225386-32-3 - Names and Identifiers
225386-32-3 - Physico-chemical Properties
Molecular Formula | C15H21NO4
|
Molar Mass | 279.33 |
Storage Condition | Store at RT. |
225386-32-3 - Introduction
Z-N-Me-Nle-OH(Z-N-Me-Nle-OH) is an organic compound whose chemical structure is a derivative of the amino acid L-norleucine. The following is a description of its nature, use, preparation and safety information:
Nature:
1. Appearance: white solid
2. Molecular formula: C13H17NO4
3. Molecular weight: 247.28g/mol
4. Melting Point: 165-167 C
5. Solubility: Soluble in some organic solvents such as methanol, dichloromethane
Use:
1. Z-N-Me-Nle-OH is often used in chemical synthesis process, as the synthesis of new drugs or bioactive molecules intermediates.
2. Can be used for the preparation of polypeptide compounds or peptide drugs with biological activity.
Method:
The preparation method of the Z-N-Me-Nle-OH can be carried out by the following steps:
1. Reaction of L-norleucine with P-chlorobenzoic acid (Cbz-Cl) to generate Cbz-N-norleucine (Z-Nle-OH).
2. Cbz-N-norleucine reacts with methylmagnesium bromide (MeMgBr) to generate Z-N-Me-Nle-OH(Z-N-Me-Nle-OH).
Safety Information:
1. Z-N-Me-Nle-OH toxicity and low risk, but still need to pay attention to safe operation.
2. During preparation and operation, appropriate protective measures should be taken, such as wearing gloves, glasses and laboratory coats.
3. Avoid inhalation, ingestion and contact with skin, such as accidental contact should immediately rinse with plenty of water.
4. In storage and handling, should avoid contact with oxidants and strong acid and alkali.
5. When using or handling the compound, refer to the relevant safety operation guide and Material Safety Data Sheet (MSDS).
Last Update:2024-04-09 02:00:44