acid is an organic compound with the chemical formula C12H16BFNO4.
Nature:
-Appearance: White crystalline solid
-Melting Point: about 160-165 ° C
-Solubility: Soluble in alcohol, Ester and Ketone solvents, slightly soluble in non-polar solvents such as benzene and ether
-Stability: stable at room temperature, but avoid contact with strong oxidants and strong acids
Use:
-acid is an important reagent in organic synthesis, mainly used to construct carbon-boron bonds, participate in Phenylboronic acid coupling reaction, boron indene reaction, selective fluorination reaction, etc.
-In the field of medicine, it is often used in the synthesis of target compounds in drug development and drug synthesis
Method:
The preparation method of acid is more complicated. A common method is as follows:
-At low temperature, 3-fluoronitrophenylboronic acid is reacted with carbamate to synthesize 3-fluoronitro-4-aminophenylboronic acid
-React the synthesized 3-fluoronitro-4-aminophenylboronic acid with tert-butyl difluoroformamide ester to generate acid
Safety Information:
-the specific safety information of acid needs to be evaluated according to the safety data sheet provided by the supplier
-When conducting experiments, it is necessary to take appropriate protective measures, such as wearing gloves, protective glasses and laboratory clothes, to prevent skin contact and eye contact
-Do not inhale, avoid swallowing
-Should be operated in a well-ventilated place, away from open flames and heat sources