Molecular Formula | C12H23NO10S3 |
Molar Mass | 437.51 |
Density | 1.78±0.1 g/cm3 (20 ºC 760 Torr) |
Solubility | Soluble in water, methanol, DMSO |
Appearance | White powder |
pKa | -2.93±0.18(Predicted) |
Storage Condition | 2-8°C |
MDL | MFCD08460269 |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from semen raphani. |
In vivo study | Glucoraphanin reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2 −/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2 −/− mice. Glucoraphanin alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice. |
Reference Show more | 1. Jiang Rui, Li Hongyan, Xue Changhu. Effects of different treatments on sulforaphane and sulforaphane in semen raphani [J]. Food Science and Technology 2019 v.44;No.337(11):91-97. 2. Zhang Rui, Yu Jianli, Song Xuan, Yan Yuanyuan, Li Chao. Antibacterial activity and in vitro immune activity of sulfatide extract from broccoli and Raphanus sativus [J]. Food Research and Development, 2021,42(04):1-7. |