211320-77-3 - Names and Identifiers
211320-77-3 - Physico-chemical Properties
Molecular Formula | C10H9ClN2O2
|
Molar Mass | 224.64 |
Density | 1.321 |
Boling Point | 345.5±37.0 °C(Predicted) |
Flash Point | 162.8°C |
Vapor Presure | 0.000122mmHg at 25°C |
pKa | 0.60±0.30(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Refractive Index | 1.604 |
211320-77-3 - Introduction
4-choro-7, 8-dimethoxyquinazoline is an organic compound. Its chemical formula is C11H10ClNO2 and its molecular weight is 227.65g/mol. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 4-choro-7, 8-dimethoxyquinazoline is a white to light yellow crystalline solid.
-Melting point: Its melting point range is 113-115 degrees Celsius.
-Solubility: It has good solubility in commonly used organic solvents (such as methanol, ethanol, dimethylformamide, etc.).
Use:
-Drug research: 4-chroo-7, 8-dimethoxyquinazoline is used as an intermediate for targeted anti-cancer drugs in the field of drug research.
-Chemical synthesis: It can also be used to synthesize other organic compounds, such as oxidized ketones and pyran compounds.
Method:
The preparation of 4-cholo-7, 8-dimethoxyquinazoline is usually carried out by the following steps:
1. React 4-chloroquinazoline with alkaline methanol to generate 4-chloro-7, 8-dimethylquinazoline.
2. The further product is reacted with methyl bromide to form 4-Chloro-7,8-dimethoxyquinazoline.
Safety Information:
- 4-Chloro-7,8-dimethoxyquinazoline needs to be stored in a cool, dry, well-ventilated place, away from direct sunlight.
-Avoid inhalation, swallowing or contact with skin during use. Proper protective equipment such as gloves and goggles must be worn.
-In the event of inhalation or exposure, clean the affected area immediately and seek medical assistance.
-If waste from this compound is to be disposed of, it should be disposed of in accordance with the relevant waste disposal regulations.
Last Update:2024-04-09 02:00:44