Molecular Formula | C36H56O12 |
Molar Mass | 680.83 |
Density | 1.39 |
Melting Point | 201-204℃ |
Boling Point | 853.6±65.0 °C(Predicted) |
Specific Rotation(α) | +49 (c, 0.8 in EtOH) |
Solubility | DMSO:100 mg/mL (146.88 mM) |
Appearance | White needle crystal powder |
Color | White to Off-White |
pKa | 4.15±0.70(Predicted) |
Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
Stability | Hygroscopic |
Sensitive | Easily absorbing moisture |
MDL | MFCD20527302 |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, derived from Polygala tenuifolia. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
HS Code | 29389090 |
Reference Show more | 1. Wang Jiancheng. Optimization of Macroporous Resin Purification Process for Qiangzhi Yishen Capsule [J]. Chinese Journal of Experimental Prescribes, 2015. 2. Jiao Yang, Ding Jingxin, Sun Xiangming, et al. Optimization of Extraction Process for Modified Suanzaoren Decoction Granules by Orthogonal Test [J]. Journal of Harbin University of Commerce (Natural Science Edition), 2017, 33(002):138-144. 3. Yue Zhenggang, xie Pei, Liu Hongbo, et al. Study on Alkali Hydrolysis Preparation Process of Polygala tenuifolia Saponin [J]. Clinical Medical Research and Practice, 2018(32). 4. [IF = 3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, A traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS." J Pharmaceut Biomed. 2021 May;198:114002 |
effect | Polygala tenuifolia saponin has the effect of improving cognitive impairment and treating dementia. Modern research shows that the chemical components of Polygala tenuifolia (especially saponins) have various pharmacological effects. Some studies have found that polygala sapogenin can improve the learning and memory ability of Alzheimer's disease (Alzheimer disease,AD) model mice. However, the properties of the sapogenin of Polygala tenuifolia are unstable and have certain hemolytic toxicity, which greatly limits the clinical application. As the main product of the alkali hydrolysis of Polygala tenuifolia saponin, Polygala tenuifolia saponin, its hemolysis and other toxic and side effects basically disappeared, and has strong anticholinesterase activity. |
biological activity | Tenuifolin is a triterpene isolated from Polygala tenuifolia and has neuroprotective effect. Tenuifolin reduces Aβ protein secretion by inhibiting β-secretase. Tenuifolin can improve the learning and memory ability of aging mice by reducing AChE activity and has potential for research on Alzheimer's disease (AD). |
target | IC50: β-secretase; ACHE |
use | tenuifolia saponin can be used to treat insomnia, dreaminess, forgetfulness and palpitations caused by heart and kidney incompatibility. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: expectorant, antitussive and antihypertensive effects. |