Name | 2-(2-AMINO-4-BIPHENYL)PROPIONITRILE |
Synonyms | 2-(2-AMINO-4-BIPHENYL)PROPIONITRILE 2-Amino-methyl-(1,1'-biphenyl)-4-acetonitrile [1,1'-Biphenyl]-4-acetonitrile, 2-amino-α-methyl- |
CAS | 132249-12-8 |
Molecular Formula | C15H14N2 |
Molar Mass | 222.29 |
Physical and Chemical Properties | Crystallization. Melting point 66-67.5 ℃. |
Use | an intermediate of flurbiprofen. |
production method | 2-phenylpropionitrile is produced by methylation of phenylacetonitrile with dimethyl sulfate, followed by nitration, reduction and acetylation, nitration, 2-(4-acetylamino-3-nitrophenyl) propionitrile was obtained, and the acetyl group was removed by hydrolysis, and then mixed with benzene in copper powder, trichloroacetic acid, amyl nitrite was reacted to obtain 2-(2-nitro-4-biphenylyl) propionitrile, and finally reduced to obtain the product. |