2-ethyl-1,3-thiazole-5-carboxylic acid

2-ethyl-1,3-thiazole-5-carboxylic acid - Names and Identifiers

Name	2-ethyl-1,3-thiazole-5-carboxylic acid
Synonyms	RU-22156 2-Ethyl 5-thiazolecarboxylic acid 2-Ethyl-5-thiazolecarboxylic acid 5-Thiazolecarboxylic acid, 2-ethyl- 2-ethyl-1,3-thiazole-5-carboxylic acid
CAS	30709-68-3
InChI	InChI=1/C6H7NO2S/c1-2-5-7-3-4(10-5)6(8)9/h3H,2H2,1H3,(H,8,9)

2-ethyl-1,3-thiazole-5-carboxylic acid - Physico-chemical Properties

Molecular Formula	C6H7NO2S
Molar Mass	157.19
Density	1.337±0.06 g/cm3(Predicted)
Boling Point	305.1±15.0 °C(Predicted)
Flash Point	138.3°C
Vapor Presure	0.000368mmHg at 25°C
pKa	3.70±0.10(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.581

2-ethyl-1,3-thiazole-5-carboxylic acid - Introduction

2-ethyl-1,3-thiazole-5-carboxylic acid(2-ethyl-1,3-thiazole-5-carboxylic acid) is an organic compound with the molecular formula C7H9NO2S. The following is a description of its nature, use, preparation and safety information:

Nature:
2-ethyl-1,3-thiazole-5-carboxylic acid is a colorless to pale yellow crystal or crystalline powder. It is sparingly soluble in water and soluble in organic solvents such as ethanol and dimethylformamide. 2-ethyl-1,3-thiazole-5-carboxylic acid has a certain acidity and can be synthesized from ketone or acid chloride and other compounds through the reaction of thiazole ring.

Use:
2-ethyl-1,3-thiazole-5-carboxylic acid has certain application value in the field of medicine, and is mainly used as an intermediate for the synthesis of drugs and biologically active compounds. It plays an important role in the introduction of thiazolone functional groups in the synthesis of various organic compounds. In addition, 2-ethyl-1,3-thiazole-5-carboxylic acid can also be used as a catalyst for organic synthesis reactions.

Method:
The synthesis method of 2-ethyl-1, 3-thiazole-5-carbylic acid can adopt many ways, such as amide acidification method, amide carbon sulfide method, etc. One of the commonly used synthetic methods is through the synthesis of ethyl ketone ring, using 2-methylthiazolyl chloride and acetoin as raw materials, under the action of catalyst, through a series of reaction steps, to obtain 2-ethyl-1,3-thiazole-5-carboxylic acid.

Safety Information:
2-ethyl-1,3-thiazole-5-carboxylic acid is stable under normal conditions, but may burn in the presence of high temperatures, sparks or open flames. It is an irritating compound and should avoid contact with the skin and eyes. Wear appropriate protective equipment such as lab gloves and goggles during operation. During use or storage, keep a well-ventilated environment away from fire and oxidizing agents.

Last Update：2024-04-09 20:52:54