2-chloroquinoline-4-carbonyl chloride

2-chloroquinoline-4-carbonyl chloride - Names and Identifiers

Name	2-chloroquinoline-4-carbonyl chloride
Synonyms	2-CHLORO QUINOLINE-4-CHLOROFORMYL 2-ChloroQuinonline-4-Chloroformyl 2-CHLORO QUINOLINE-4-FORMYL CHLORIDE 2-Chloroquinoline-4-carbonyl chloride 2-Chloro-4-quinolinecarbonyl chloride 2-chloroquinoline-4-carbonyl chloride 2-CHLORO-QUINOLINE-4-CARBONYL CHLORIDE 4-Quinolinecarbonyl chloride, 2-chloro- 4-hydroxy-1-(phenylmethyl)-4-piperidinecarboxylic acid ethyl ester
CAS	2388-32-1
EINECS	219-220-5
InChI	InChI=1/C10H5Cl2NO/c11-9-5-7(10(12)14)6-3-1-2-4-8(6)13-9/h1-5H

2-chloroquinoline-4-carbonyl chloride - Physico-chemical Properties

Molecular Formula	C10H5Cl2NO
Molar Mass	226.06
Density	1.457±0.06 g/cm3(Predicted)
Melting Point	89 °C(Solv: benzene (71-43-2))
Boling Point	170 °C(Press: 1.0 Torr)
Flash Point	160.2°C
Vapor Presure	8.17E-05mmHg at 25°C
pKa	-2.82±0.50(Predicted)
Storage Condition	2-8°C
Refractive Index	1.66

2-chloroquinoline-4-carbonyl chloride - Introduction

chloride is an organic compound with the chemical formula C10H5Cl2NO, which is a derivative of quinoline compounds. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: chloride is a white crystal or crystalline powder.
-Solubility: Soluble in organic solvents such as chloroform, dichloromethane, slightly soluble in alcohol, insoluble in water.
-Melting point: About 90 ° C
-Stability: The compound is stable under light, but it is susceptible to moisture and decomposition in the air.

Use:
-Chemical reagent: chloride can be used as an intermediate for the preparation of other organic compounds, such as drugs, pesticides, etc.
-Synthesis of quinoline drugs: This compound can be used to prepare quinoline drugs, such as quinine and chloroquine.

Method:
The preparation of chloride can be carried out by the following steps:
1. Reacting 2-chloroquinoline with anhydrous dichloromethane to prepare a solution of 2-chloroquinoline in dichloromethane.
2. Add formyl chloride to 2-chloroquinoline dichloromethane solution to react to generate chloride.
3. Filtration and crystallization give the product.

Safety Information:
-chloride is an organic synthetic reagent and has certain risks. Wear protective equipment during operation and avoid contact with skin, eyes and respiratory tract.
-The compound should be kept away from sources of fire and stored in a dry, cool place.
-Follow laboratory safety regulations during use or storage to avoid reactions with other chemicals. In the event of an accident, immediately take appropriate first aid measures and seek professional medical help.

Last Update：2024-04-09 15:17:56