2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE

2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Names and Identifiers

Name	2-Fluoro-6-(trifluoromethyl)benzylamine
Synonyms	OTF-BYM-6F Z1R BF FXFFF elagolix intermediate 1 2-Fluoro-6-(trifluoromethyl)benzylamine 2-Chloro-6-(trifluoromethyl)benzylamine 2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE (2-fluoro-6-(trifluoroMethyl)phenyl)MethanaMine 1-[2-Fluoro-6-(trifluoromethyl)phenyl]methanamine benzenemethanamine, 2-fluoro-6-(trifluoromethyl)- (2-fluoro-6-(trifluoroMethyl)phenyl)MethanaMine hydrochloride 2-(Aminomethyl)-3-fluorobenzotrifluoride, [2-Fluoro-6-(trifluoromethyl)phenyl]methylamine
CAS	239087-06-0
InChI	InChI=1/C9H10F3N/c1-6-3-2-4-8(7(6)5-13)9(10,11)12/h2-4H,5,13H2,1H3

2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Physico-chemical Properties

Molecular Formula	C8H7F4N
Molar Mass	193.14
Density	1.312±0.06 g/cm3(Predicted)
Boling Point	173.2±35.0 °C(Predicted)
pKa	7.84±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Sensitive	Air Sensitive
Refractive Index	1.4925

2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
Hazard Note	Corrosive/Store under nitrogen
Hazard Class	8

2-FLUORO-6-(TRIFLUOROMETHYL)BENZYLAMINE - Introduction

2-Fluoro-6-(trifluoromethyl)benzylamine is an organic compound with the chemical formula C8H6F4N and a molecular weight of 205.13. It is a colorless liquid and a volatile solid at room temperature. The following is a detailed description of the nature, use, preparation and safety information of 2-Fluoro-6-(trifluoromethyl) benzene:

Nature:
-Appearance: colorless liquid
-Melting point: -5 ° C
-Boiling point: 146-148 ° c
-Density: 1.351g/cm³
-Refractive Index: 1.477

Use:
2-Fluoro-6-(trifluoromethyl)benzylamine is widely used in organic synthesis, pharmaceutical chemistry and pesticide manufacturing. It is one of the important intermediates in the synthesis of many drugs and pesticides. It can be used as substrate, reagent, solvent and catalyst in organic synthesis.

Method:
2-Fluoro-6-(trifluoromethyl)benzylamine can be synthesized by the following steps:
1. 2-fluoro-6-iodobenzyl alcohol is reacted with trifluoromethyl amine to generate a precursor compound of 2-Fluoro-6-(trifluoromethyl)benzylamine.
2. Alkaline hydrolysis with sodium hydroxide solution to give 2-Fluoro-6-(trifluoromethyl) benzene amine.

Safety Information:
2-Fluoro-6-(trifluoromethyl)benzylamine should be used with caution and follow safe operating methods. During operation and storage, contact with oxidants, strong acids and strong bases should be avoided. Wear appropriate personal protective equipment such as goggles and protective gloves. In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical help. This compound is less toxic and irritating, but it is still recommended to maintain well-ventilated laboratory conditions during operation. To ensure safety, it is recommended to operate and handle this compound under the guidance of suitable institutions or professionals.

Last Update：2024-04-09 15:17:56