2-Cyclopropylpyrimidin-5-amine, also known as 2-(3-propenyl) pyrimidin-5-amine, is an organic compound. The following is a detailed description of its nature, use, preparation and safety information:
Nature:
2-Cyclopropylpyrimidin-5-amine is a colorless to light yellow solid. It is soluble in organic solvents such as dichloromethane and ethanol at room temperature, but poorly soluble in water. It has a pyrimidine ring and propenyl side chain structure.
Use:
2-cyclopropylpyrimidin-5-amine is widely used in organic synthesis. It acts as an inhibitor of DNA polymerase and can be used to inhibit cellular DNA replication. In addition, it can also be used in the synthesis of pyrimidine anticancer drugs and other biologically active compounds.
Preparation Method:
2-cyclopropylpyrimidin-5-amine can be prepared by reacting 2-pyrimidinol with propylene formaldehyde under alkaline conditions. The specific reaction conditions can be adjusted according to actual needs.
Safety Information:
Regarding the safety of 2-cyclopropylpyrimidin-5-amine, there is no clear toxicity information and carcinogenicity evaluation results, so care should be taken when using and handling. In case of contact, care should be taken to avoid direct contact with skin and eyes and to avoid inhaling its powder or gas. It is recommended to wear appropriate personal protective equipment, such as safety glasses, gloves and protective face masks. At the same time, it is recommended to operate in a well-ventilated environment. Seek medical help as soon as possible in case of discomfort or unforeseen circumstances. Please be sure to refer to the relevant chemical safety data and operating instructions to use the compound according to the actual situation.