Molecular Formula | C7H5FN2S |
Molar Mass | 168.19 |
Density | 1.3490 (estimate) |
Melting Point | 183-185 °C (lit.) |
Boling Point | 312.0±34.0 °C(Predicted) |
Flash Point | 30.6°C |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 9.22mmHg at 25°C |
Appearance | White solid |
Color | Off-white to tan |
pKa | 3.77±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.501 |
MDL | MFCD00013336 |
Physical and Chemical Properties | melting point 181-185°C |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
WGK Germany | 3 |
HS Code | 29342000 |
Hazard Class | IRRITANT |
Introduction | 2-amino-6-fluorobenzothiazole is an intermediate for the synthesis of benzothiamide. Phenthamide is a new type of amino acid carbamate fungicide and a green agricultural fungicide with a wide range of uses. Amino acid pesticides refer to chemical products containing the basic structure of amino acids, such as N-methylene phosphate-glycine compounds, etc. These pesticides are characterized by no acute toxicity to humans and animals, can be decomposed by microorganisms, and do not cause residual pollution. |
preparation | add 9 L dimethyl sulfoxide to a 20 L three-mouth flask, add 1 kg (8.62 mol) p-fluorocyclohexanone, 0.66kg (8.62 mol) thiourea, 0.66kg(2.6 mol) iodine and 7.4kg(43 mol) p-methenesulfonic acid under mechanical stirring, and then bounce into air, the heating control reaction temperature is around 70 ℃, the reaction is overnight, and the system is brownish red or light yellow. After the reaction is completed, water is added to terminate the reaction, ethyl acetate is extracted, organic layers are combined, dried with anhydrous sodium sulfate, and distilled under reduced pressure to remove the solvent to obtain a white solid of about 1.36 kg, with a yield of 94%. |