2-氨基-3-氰基-5-溴吡嗪

2-氨基-3-氰基-5-溴吡嗪 - Names and Identifiers

Name	3-Amino-6-Bromopyrazine-2-Carbonitrile
Synonyms	2-AMINO-5-BROMO-3-CYANOPYRAZINE 2-Amino-3-cyano-5-bromopyrazine 2-Amino-5-Bromo-3-Cyanopyrazine 3-AMINO-6-BROMOPYRAZINE-2-CARBONITRILE 3-Amino-6-Bromopyrazine-2-Carbonitrile 2-Pyrazinecarbonitrile, 3-amino-6-bromo-
CAS	17231-51-5
InChI	InChI=1/C5H3BrN4/c6-4-2-9-5(8)3(1-7)10-4/h2H,(H2,8,9)

2-氨基-3-氰基-5-溴吡嗪 - Physico-chemical Properties

Molecular Formula	C5H3BrN4
Molar Mass	199.01
Density	1.94±0.1 g/cm3(Predicted)
Melting Point	183-184 °C(Solv: benzene (71-43-2))
Boling Point	341.0±42.0 °C(Predicted)
Flash Point	160.026°C
Vapor Presure	0mmHg at 25°C
pKa	-0.11±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.67
MDL	MFCD06658300

2-氨基-3-氰基-5-溴吡嗪 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R41 - Risk of serious damage to eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection.

2-氨基-3-氰基-5-溴吡嗪 - Introduction

It is an organic compound with the chemical formula C5H2BrN5. The following is a detailed description of the properties, uses, preparation and safety information of the compound:

1. Nature:
-Appearance: Colorless or yellowish crystals.
-Melting point: About 280-283 degrees Celsius.
-Solubility: Soluble in chloroform, ethanol, dimethylformamide and other organic solvents, slightly soluble in water.
-Stability: Stable at room temperature and pressure.

2. Use:
is a pharmaceutical intermediate commonly used in the synthesis of drugs or pesticides. It can be used as a lead compound for antitumor drugs, antibiotics and antifungal drugs. In addition, it can also be used to synthesize organic dyes and photosensitive materials.

3. Preparation method:
Generally, the synthesis of phosphonium is mainly accomplished by the reaction of cyanogen dichloride and pyrazine. The specific synthetic route is as follows:
First, Cyanogen dichloride and pyrazine are reacted to produce 2-amino-5-cyano-3-pyrazine iodide.
Then, 2-amino -5-cyano -3-pyrazine iodide is reacted with hydrogen bromide to obtain pyridine.

4. Safety Information:
-is an organic compound, need to pay attention to protective measures when using.
-This compound is irritating to the eyes, skin and respiratory tract. Use should wear protective glasses, gloves and masks.
-Avoid contact with oxidants, strong acids and alkalis during storage, handling and use to avoid dangerous reactions.
-If you accidentally inhale or come into contact with skin or eyes, rinse immediately with water, and seek medical attention as soon as possible if you do not adapt.

Please strictly follow the safety procedures when using this compound, and operate it through an appropriate chemical laboratory or professional organization.

Last Update：2024-04-09 21:01:54