Molecular Formula | C38H52N6O7 |
Molar Mass | 704.86 |
Density | 1.178±0.06 g/cm3(Predicted) |
Melting Point | 207-2090C |
Specific Rotation(α) | D -47° (c = 1 in ethanol) |
Solubility | Soluble in methanol, ethanol (~2 mg/ml), DMSO (~16 mg/ml), DMF (~25 mg/ml), and DMF:PBS |
Appearance | Crystalline solid |
Color | white to beige |
pKa | 11.11±0.46(Predicted) |
Storage Condition | -20°C |
Refractive Index | 1.562 |
Use | A highly potent HIV-1 protease inhibitor |
In vitro study | Atazanavir has potent activity against wild-type virus in vitro with EC50 and EC90 at 2-5 nM and 9-15 nM, respectively. Atazanavir can effectively induce endoplasmic reticulum stress response in malignant glioma cells, GRP78 and CHOP levels are increased, caspase-4 is activated, leading to cell death. |
In vivo study | Atazanavir has good oral bioavailability, and its availability is 60-70%. |