Molecular Formula | C23H25NO4 |
Molar Mass | 379.45 |
Density | 1.238 |
Melting Point | 161-187℃ |
Boling Point | 602.9±38.0 °C(Predicted) |
Appearance | White to off-white powder |
pKa | 3.89±0.10(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Hazard Class | IRRITANT |
Use | Fluorene methoxycarbonyl D-cyclohexylglycine is a common pharmaceutical and chemical intermediate, fluorenyl chloride (FMOC-Cl) is a chloroformate. It is used to form fluorene methoxycarbonyl (FMOC group) into fluorene methoxycarbonyl carbamate FMOC carbamate, which is a common amino protecting group. |
Preparation | The synthesis of fluorene methoxycarbonyl D-cyclohexylglycine has been reported in the literature. Using cyclohexyl bromide as the raw material, in the presence of sodium alkoxide, it undergoes a alkylation reaction with diethyl malonate, and then hydrolyzes, acidifies, and decarboxylates to obtain cyclohexyl acetic acid; the latter is then brominated and ammonolysis DL-Cyclohexylglycine; finally, acylation reaction occurs in the presence of fluorene methoxycarbonyl chloride to obtain fluorene methoxycarbonyl D-cyclohexylglycine [1]. The synthesis reaction route is as follows: |